Title:
METHOD AND MEDICINE FOR LOSING WEIGHT AND REDUCING BLOOD GLUCOSE AND BLOOD LIPID VIA MIR-96, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/192669
Kind Code:
A1
Abstract:
Provided is a use in preventing and/or treating, by inhibiting a miR-96 function, hyperlipidemia, fatty liver, obesity, diabetes and symptoms similar to the symptoms of the above diseases. Also provided is a method for inhibiting the miR-96 function, comprising enabling a miR-96 inhibitor such as an antisense oligonucleotide to contact a target cell expressing miR-96. Also provided are an inhibitor inhibiting the miR-96 function, pharmaceutical composition and kit comprising the inhibitor, and use thereof in preventing and/or treating hyperlipidemia, fatty liver, obesity, diabetes and symptoms similar to the symptoms of the above diseases.
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Inventors:
PENG CHANGGENG (CN)
WEN TING (CN)
WEN TING (CN)
Application Number:
PCT/CN2016/084710
Publication Date:
December 08, 2016
Filing Date:
June 03, 2016
Export Citation:
Assignee:
PENGEKIPHEN BIOTECH LTD (CN)
International Classes:
A61K48/00; A61K31/7088; A61P1/16; A61P3/04; A61P3/06; A61P3/10
Domestic Patent References:
| WO2013159091A2 | 2013-10-24 |
Foreign References:
| CN103961706A | 2014-08-06 |
Other References:
LI, WANG ET AL.: "MicroRNAs 185, 96, and 223 Repress Selective High-Density Lipoprotein Cholesterol Uptake through Posttranscriptional Inhibition", MOLECULAR AND CELLULAR BIOLOGY, vol. 33, no. 10, 31 May 2013 (2013-05-31), pages 1956 - 1964, XP055332650, ISSN: 0270-7306
CHAKRABORTY, C. ET AL.: "Influence of miRNA in Insulin Signaling Pathway and Insulin Resistance: Micro-molecules with a Major Role in Type-2 diabetes", WILEY INTERDISCIPLINARY REVIEWS-RNA, vol. 5, no. 5, 31 October 2014 (2014-10-31), pages 697 - 712, XP055332657, ISSN: 1757-7004
CHAKRABORTY, C. ET AL.: "Influence of miRNA in Insulin Signaling Pathway and Insulin Resistance: Micro-molecules with a Major Role in Type-2 diabetes", WILEY INTERDISCIPLINARY REVIEWS-RNA, vol. 5, no. 5, 31 October 2014 (2014-10-31), pages 697 - 712, XP055332657, ISSN: 1757-7004
Attorney, Agent or Firm:
RUNPING&PARTNERS (CN)
北京润平知识产权代理有限公司 (CN)
北京润平知识产权代理有限公司 (CN)
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