Title:
METHOD FOR MODIFYING AMINO GROUP IN MOLECULE WITH OXAZOLINE QUATERNARY AMMONIUM SALT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/207279
Kind Code:
A1
Abstract:
The present invention relates to a method for modifying or marking an amino group in a molecule, wherein the amino group in the molecule is modified or marked with oxazoline quaternary ammonium salt shown in the following formula 1, wherein the molecule comprises amino acid ester, aminoamide, or peptide/protein. The method has advantages of economy and site selectivity, and has huge potential application value in the field such as pharmaceutical molecular synthesis, probe molecule and diagnostic marker reagent development.
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Inventors:
LI BO (CN)
LIU PENG (CN)
SUN HAIGUO (CN)
XI MENGYU (CN)
XU ZHIJIAN (CN)
ZHANG YONG (CN)
ZHU WEILIANG (CN)
LIU PENG (CN)
SUN HAIGUO (CN)
XI MENGYU (CN)
XU ZHIJIAN (CN)
ZHANG YONG (CN)
ZHU WEILIANG (CN)
Application Number:
PCT/CN2020/081983
Publication Date:
October 15, 2020
Filing Date:
March 30, 2020
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D498/04; C07D213/64
Foreign References:
| CN107759614A | 2018-03-06 | |||
| CN107759614A | 2018-03-06 |
Other References:
PENG LIU ET AL.: "Metal-free quinolylation of the primary amino groups of amino acid derivatives and peptides with dihydrooxazolo[3, 2-a]quinoliniums", GREEN CHEMISTRY, vol. 21, no. 15, 12 July 2019 (2019-07-12), XP055741308, DOI: 20200623201023PX
LI, BO ET AL.: "Regioselectivity and Mechanism of Synthesizing N-Substituted 2-Pyridones and 2-Substituted Pyridines via Metal-Free C-O and C-N Bond-Cleaving of Oxazoline[3, 2-a]pyridiniums", SCIENTIFIC REPORTS, no. 7, 25 January 2017 (2017-01-25), XP055469977, DOI: 20200623200800X
LI, BO ET AL.: "initially discovered a new acetal rearrangement reaction and a novel class of N-substituted aryl isoquinolinone compounds with good anti-tumor activity prepared thereby", EUR. J. MED. CHEM., vol. 77, 2014, pages 204 - 210
EUR. J. MED. CHEM., vol. 70, 2013, pages 677
SCI REP., vol. 7, 2017, pages 41287
CANCER LETT., vol. 421, 2018, pages 135 - 144
LI, BO ET AL.: "Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement", EUR. J. MED. CHEM., vol. 77, 2014, pages 204 - 210, XP028843704, DOI: 10.1016/j.ejmech.2014.03.008
See also references of EP 3954692A4
LI, BO ET AL.: "Regioselectivity and Mechanism of Synthesizing N-Substituted 2-Pyridones and 2-Substituted Pyridines via Metal-Free C-O and C-N Bond-Cleaving of Oxazoline[3, 2-a]pyridiniums", SCIENTIFIC REPORTS, no. 7, 25 January 2017 (2017-01-25), XP055469977, DOI: 20200623200800X
LI, BO ET AL.: "initially discovered a new acetal rearrangement reaction and a novel class of N-substituted aryl isoquinolinone compounds with good anti-tumor activity prepared thereby", EUR. J. MED. CHEM., vol. 77, 2014, pages 204 - 210
EUR. J. MED. CHEM., vol. 70, 2013, pages 677
SCI REP., vol. 7, 2017, pages 41287
CANCER LETT., vol. 421, 2018, pages 135 - 144
LI, BO ET AL.: "Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement", EUR. J. MED. CHEM., vol. 77, 2014, pages 204 - 210, XP028843704, DOI: 10.1016/j.ejmech.2014.03.008
See also references of EP 3954692A4
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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