Title:
METHOD OF MODULATING DRUG RELEASE FROM A COATED SUBSTRATE
Document Type and Number:
WIPO Patent Application WO2006088676
Kind Code:
A3
Abstract:
A method of modulating drug release from coated substrates by modulating the drying rate of the coatings on the substrates. Each coating is a mixture of a polymer, a solvent, and drug and the method includes modulating the release rate of the drug particles from the outer surface of the coatings by drying the solvent of each of the mixtures at different drying rates. A decrease in the drying rate of the solvent increases the initial release rate of the drug and an increase in the drying rate of the solvent decreases the initial release rate of the drug.
Inventors:
KANGAS STEVE (US)
Application Number:
PCT/US2006/004023
Publication Date:
November 09, 2006
Filing Date:
February 03, 2006
Export Citation:
Assignee:
BOSTON SCIENT SCIMED INC (US)
KANGAS STEVE (US)
KANGAS STEVE (US)
International Classes:
A61K31/337; A61F2/82; A61L31/10; A61L31/16
Domestic Patent References:
| WO2003090806A1 | 2003-11-06 | |||
| WO2004000267A1 | 2003-12-31 | |||
| WO2004000380A1 | 2003-12-31 | |||
| WO2004091714A2 | 2004-10-28 | |||
| WO2005011767A1 | 2005-02-10 |
Other References:
YAMAGUCHI Y ET AL: "RELEASE OF CLONIDINE HYDROCHLORIDE FROM PRESSURE-SENSITIVE ADHESIVEMATRICES PREPARED BY EMULSION-TYPE ACRYLATE POLYMERS", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 43, no. 10, 1 October 1995 (1995-10-01), pages 1807 - 1809, XP000537681, ISSN: 0009-2363
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