Title:
METHOD FOR MODULATING METABOLISM
Document Type and Number:
WIPO Patent Application WO/2019/140052
Kind Code:
A1
Abstract:
A method for modulating metabolism is provided which includes the step of providing a consumable composition including an extract containing a compound of Formula I to a subject in need thereof thereby modulating the subject's metabolism and addressing the underlying pathogenesis of metabolic disorders, such as nonalcoholic fatty liver disease, nonalcoholic steatohepatitis and type II diabetes mellitus.
Inventors:
CHAE LEE (US)
Application Number:
PCT/US2019/012993
Publication Date:
July 18, 2019
Filing Date:
January 10, 2019
Export Citation:
Assignee:
BRIGHTSEED INC (US)
International Classes:
A61K31/715; A61K36/185; A61P3/06
Other References:
NISHIOKA ET AL.: "Isolation and Activity of N-p-Coumaroyltyramine, an (X-Glucosidase Inhibitor in Welsh Onion (Allium fistulosum", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 61, no. 7, 1997, pages 1138 - 1141, XP002740482, doi:10.1271/bbb.61.1138
AMARO ET AL.: "Hypoglycemic and Hypotensive Activity of a Root Extract of Smilax aristolochiifolia, Standardized on N-trans-Feruloyl-Tyramine", MOLECULES, vol. 19, no. 8, 31 July 2014 (2014-07-31), pages 11366 - 11384, XP055623905
LEE ET AL.: "Anti-inflammatory effect of tribulusamide D isolated from Tribulus terrestris in lipopolysaccharide-stimulated RAW264.7 macrophages", MOLECULAR MEDICINE REPORTS, vol. 16, no. 4, 10 August 2017 (2017-08-10), pages 4421 - 4428, XP055623908
AL-TAWEEL ET AL.: "Bioactive Phenolic Amides from Celtis africana", MOLECULES, vol. 17, no. 3, 5 March 2012 (2012-03-05), pages 2675 - 2682, XP055623911
MACIEL ET AL.: "New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae", MOLECULES, vol. 21, no. 11, 2016, pages 13, XP055623915
See also references of EP 3737389A4
AMARO ET AL.: "Hypoglycemic and Hypotensive Activity of a Root Extract of Smilax aristolochiifolia, Standardized on N-trans-Feruloyl-Tyramine", MOLECULES, vol. 19, no. 8, 31 July 2014 (2014-07-31), pages 11366 - 11384, XP055623905
LEE ET AL.: "Anti-inflammatory effect of tribulusamide D isolated from Tribulus terrestris in lipopolysaccharide-stimulated RAW264.7 macrophages", MOLECULAR MEDICINE REPORTS, vol. 16, no. 4, 10 August 2017 (2017-08-10), pages 4421 - 4428, XP055623908
AL-TAWEEL ET AL.: "Bioactive Phenolic Amides from Celtis africana", MOLECULES, vol. 17, no. 3, 5 March 2012 (2012-03-05), pages 2675 - 2682, XP055623911
MACIEL ET AL.: "New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae", MOLECULES, vol. 21, no. 11, 2016, pages 13, XP055623915
See also references of EP 3737389A4
Attorney, Agent or Firm:
LICATA, Jane, Massey et al. (US)
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