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Title:
METHOD FOR MONITORING BLOOD FLOW AND METABOLIC UPTAKE IN TISSUE WITH RADIOLABELED ALKANOIC ACID
Document Type and Number:
WIPO Patent Application WO2004093650
Kind Code:
A3
Abstract:
The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty acid backbone. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest.

Inventors:
ELMALEH DAVID R (US)
FISCHMAN ALAN J (US)
SHOUP TIMOTHY M (US)
Application Number:
US2004012084W
Publication Date:
April 14, 2005
Filing Date:
April 19, 2004
Export Citation:
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Assignee:
THE GENERAL HOSPITAL CORPORATION
ELMALEH, DAVID, R.
FISCHMAN, ALAN, J.
SHOUP, TIMOTHY, M.
International Classes:
A61K31/19; A61K31/20; A61K51/00; B65D71/00; C07C61/04; C07C63/33; C07F5/00; A61B; (IPC1-7): A61K31/20; A61K31/19; C07C63/33; C07C61/04; B65D71/00
Foreign References:
US4202902A1980-05-13
Other References:
JONAS ET AL.: 'Simultaneous evaluation of fatty acid metabolism and myocardial flow in an explanted heart' THE JOURNAL OF NUCLEAR MEDICINE vol. 37, no. 12, 1996, pages 1990 - 1994, XP008045225
EISENHUT ET AL.: 'Trapping and metabolism of radioiodinated PHIPA 3-10 in the rat myocardium' THE JOURNAL OF NUCLEAR MEDICINE vol. 38, no. 12, 1997, pages 1864 - 1869, XP008045226
See also references of EP 1622602A2
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