Title:
METHOD FOR NERVE DETECTION BY RAMAN SCATTERING SPECTROSCOPY
Document Type and Number:
WIPO Patent Application WO/2013/146779
Kind Code:
A1
Abstract:
The present invention provides a method for detecting nerves, wherein the method is characterized by comprising the following steps (1) to (4). Step (1): a step for irradiating a sample with excitation light; step (2): a step for detecting Raman scattering light coming from the sample; step (3): a step for either calculating the intensity ratio of a wave number within a specific range for the Raman scattering light detected in step (2), or for extracting and running a multivariate analysis and/or statistical analysis of a feature of the intensity ratio; and step (4): a step for specifically displaying nerves, including unmyelinated nerves, using as an index the intensity ratio or the result from the multivariate analysis and/or statistical analysis.
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Inventors:
TAKAMATSU TETSURO (JP)
MINAMIKAWA TAKEO (JP)
HARADA YOSHINORI (JP)
MINAMIKAWA TAKEO (JP)
HARADA YOSHINORI (JP)
Application Number:
PCT/JP2013/058775
Publication Date:
October 03, 2013
Filing Date:
March 26, 2013
Export Citation:
Assignee:
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
International Classes:
G01N21/65; A61B10/00; G01N33/48
Domestic Patent References:
| WO2010103661A1 | 2010-09-16 | |||
| WO2010103661A1 | 2010-09-16 |
Foreign References:
| JP2007108154A | 2007-04-26 | |||
| JP2000055809A | 2000-02-25 | |||
| JP2007147350A | 2007-06-14 | |||
| JP2007147357A | 2007-06-14 |
Other References:
MINAMIKAWA TAKEO: "Label-free detection of nerve tissues by spontaneous Raman microspectroscopy", ANNUAL CONFERENCE OF JAPANESE SOCIETY FOR MEDICAL AND BIOLOGICAL ENGINEERING PROGRAM-RONBUNSHU (CD-ROM), 2012, XP035156651
HAKA, A.S. ET AL., CANCER RES., vol. 66, 2006, pages 3317 - 22
MOTZ, J.T. ET AL., J. BIOMED. OPT., vol. 11, 2006, pages 021003
TORRES FILHO, I.P. ET AL., J. APPL. PHYSIOL, vol. 104, 2008, pages 1809 - 17
LIEBER, C.A.; MAHADEVAN-JANSEN, A.: "Automated Method for Subtraction of Fluorescence from Biological Raman Spectra.", APPL. SPECTROSC., vol. 57, no. 11, 2003, pages 1363 - 1367
P. MATOUSEK: "Deep non-invasive Raman spectroscopy of living tissue and powders", CHEM SOC REV, vol. 36, no. 8, 2007, pages 1292 - 304
LIEBER CA; MAHADEVAN-JANSEN A: "Automated Method for Subtraction of Fluorescence from Biological Raman Spectra.", APPL SPECTROSC, vol. 57, no. 11, 2003, pages 1363 - 1367
See also references of EP 2837335A4
HAKA, A.S. ET AL., CANCER RES., vol. 66, 2006, pages 3317 - 22
MOTZ, J.T. ET AL., J. BIOMED. OPT., vol. 11, 2006, pages 021003
TORRES FILHO, I.P. ET AL., J. APPL. PHYSIOL, vol. 104, 2008, pages 1809 - 17
LIEBER, C.A.; MAHADEVAN-JANSEN, A.: "Automated Method for Subtraction of Fluorescence from Biological Raman Spectra.", APPL. SPECTROSC., vol. 57, no. 11, 2003, pages 1363 - 1367
P. MATOUSEK: "Deep non-invasive Raman spectroscopy of living tissue and powders", CHEM SOC REV, vol. 36, no. 8, 2007, pages 1292 - 304
LIEBER CA; MAHADEVAN-JANSEN A: "Automated Method for Subtraction of Fluorescence from Biological Raman Spectra.", APPL SPECTROSC, vol. 57, no. 11, 2003, pages 1363 - 1367
See also references of EP 2837335A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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