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Title:
METHOD FOR OBTAINING 1-N-ETHYL GENTAMICIN C1A BY USING PIPELINE REACTION HYDROLYSIS
Document Type and Number:
WIPO Patent Application WO/2022/222249
Kind Code:
A1
Abstract:
Involved is a method for obtaining 1-N-ethyl gentamicin C1a by using hydrolysis in a pipeline reactor. The method comprises the following steps: 1) pumping an etimicin synthesis solution and a NaOH solution into a temporary storage tank to be hydrolyzed, and mixing to obtain a reaction mixed solution; 2) opening a pipeline reactor to enable the temperature of a pipeline to reach about 100°C; 3) pumping the reaction mixed solution in step 1) into the pipeline reactor, controlling the temperatures of the inlet and outlet of a first reaction pipeline (1) to be 95-100°C, controlling the temperatures of the inlet and outlet of a second reaction pipeline (2) to be 100-110°C, keeping the temperature of the solution at 100-105°C, and performing hydrolysis for 6 hours; 4) after the reaction is completed, opening the circulating water supply valve and the circulating water return valve of a clamping sleeve on the pipeline reactor (3), and cooling to be close to room temperature; and 5) pumping a hydrolyzed reaction solution into a hydrolysis storage tank from the pipeline reactor (3).

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Inventors:
WANG BIN (CN)
JIANG YINGQING (CN)
YOU LAN (CN)
YUAN WENJUN (CN)
LI PEIPENG (CN)
Application Number:
PCT/CN2021/099584
Publication Date:
October 27, 2022
Filing Date:
June 11, 2021
Export Citation:
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Assignee:
WUXI JIYU SHANHE PHARMACEUTICAL CO LTD (CN)
International Classes:
B01J19/24; B01J19/00; B01J19/02; B01J19/18; C07H1/06; C07H15/236
Foreign References:
CN109317082A2019-02-12
CN103395801A2013-11-20
CN111672449A2020-09-18
CN102796149A2012-11-28
CN102432647A2012-05-02
CN206701242U2017-12-05
Other References:
LU YUFENG: "Improved Synthetic Process for Etimiein sulfate", CHINESE SELECTED DOCTORAL DISSERTATIONS AND MASTER'S THESES FULL-TEXT DATABASES (DOCTORAL), ENGINEERING SCIENCE & TECHNOLOGY I, no. 4, 15 December 2004 (2004-12-15), XP055979617
Attorney, Agent or Firm:
BEIJING HUAKE UNION PATENT OFFICE(GP) (CN)
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