METHOD FOR OBTAINING 4-(N-ALKYLAMINE)-5, 6-DIHYDRO-4H-THIENO-(2,3-b)-THIOPYRAN-2-SULFAMIDE-7, 7-DIOXIDES AND INTERMEDIATE PRODUCTS

Title:

METHOD FOR OBTAINING 4-(N-ALKYLAMINE)-5, 6-DIHYDRO-4H-THIENO-(2,3-b)-THIOPYRAN-2-SULFAMIDE-7, 7-DIOXIDES AND INTERMEDIATE PRODUCTS

Document Type and Number:

WIPO Patent Application WO2002020529

Kind Code:

A8

Abstract:

The invention relates to a method for obtaining 4-(N-alkylamine)-5, 6-dihydro-4H-thieno-(2,3-b)-thiopyran-2-sulfamide-7, 7-dioxides (I), wherein R1 represents H or C1-5 alkyl and R2 represents C1-5 alkyl, from the corresponding 4-(N-alkylamine)-5, 6-dihydro-4H-thieno-(2,3-b)-thiopyran-7, 7-dioxides, comprising the protection of the alkylamine group, the introduction of the sulfonamide group and the release of the protecting group. Certain compounds (I) are carbonic anhydrase inhibitors and can be used in the treatment of high intraocular pressure.

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Inventors:

GARCIA LOSADA PABLO (ES)
SILVA GUISASOLA LUIS OCTAVIO (ES)
LORENTE BONDE-LARSEN ANTONIO (ES)
MARTIN JUAREZ JORGE (ES)

Application Number:

PCT/ES2001/000335

Publication Date:

July 25, 2002

Filing Date:

September 04, 2001

Export Citation:

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Assignee:

RAGA CONSULTORES S L (ES)
GARCIA LOSADA PABLO (ES)
SILVA GUISASOLA LUIS OCTAVIO (ES)
LORENTE BONDE-LARSEN ANTONIO (ES)
MARTIN JUAREZ JORGE (ES)

International Classes:

C07B57/00; C07D495/04; (IPC1-7): C07D495/04

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