Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR OBTAINING PRECURSOR Z AND USE THEREOF FOR THE PRODUCTION OF A MEANS FOR THERAPY OF HUMAN MOLYBDENUM COFACTOR DEFICIENCY
Document Type and Number:
WIPO Patent Application WO2005073387
Kind Code:
A3
Abstract:
The invention relates to a method for obtaining the molybdopterin derivative precursor Z, whereby an over-production of precursor Z occurs in host organisms by recombinant expression of precursor Z synthesizing proteins. The invention further relates to the use of precursor Z for the production of a means for the therapy of human molybdenum cofactor deficiency and associated diseases, which may be directly or indirectly attributed to an altered molybdenum cofactor synthesis, whereby precursor Z is used as essential component of said means.

Inventors:
SCHWARZ GUENTER (DE)
MENDEL RALF (DE)
SANTAMARIA JOSE (DE)
REISS JOCHEN (DE)
Application Number:
PCT/DE2005/000142
Publication Date:
October 27, 2005
Filing Date:
January 31, 2005
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SCHWARZ GUENTER (DE)
MENDEL RALF (DE)
SANTAMARIA JOSE (DE)
REISS JOCHEN (DE)
International Classes:
C12P9/00; C12P15/00; C12P17/18; A61K39/00; (IPC1-7): C12P9/00; C12P15/00; A61P25/00
Other References:
HAENZELMANN PETRA ET AL: "Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 21, 24 May 2002 (2002-05-24), pages 18303 - 18312, XP002337385, ISSN: 0021-9258
WUEBBENS MARGOT M ET AL: "Structural characterization of a molybdopterin precursor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 18, 1993, pages 13493 - 13498, XP002337260, ISSN: 0021-9258
SCHWARZ GUERNTER ET AL: "Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli", HUMAN MOLECULAR GENETICS, vol. 13, no. 12, 15 June 2004 (2004-06-15), pages 1249 - 1255, XP002337257, ISSN: 0964-6906
SANTAMARIA-ARAUJO JOSE ANGEL ET AL: "The tetrahydropyranopterin structure of the sulfur-free and metal-free molybdenum cofactor precursor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 16, 16 April 2004 (2004-04-16), pages 15994 - 15999, XP002337258, ISSN: 0021-9258
WUEBBENS MARGOT M ET AL: "Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 16, 18 April 2003 (2003-04-18), pages 14523 - 14532, XP002337259, ISSN: 0021-9258
GUTZKE G.: "Der zweite Schritt der Molybdäncofaktor-Biosynthese: Molekularer Mechanismus der Konversion von PrecursorZ zu Molybdopterin", 14 June 2002, XP002337437
Download PDF: