Title:
METHOD FOR OBTAINING PURE ENANTIOMERS OF A PYRIDAZINONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO1997035841
Kind Code:
A3
Abstract:
The invention provides a novel, crystalline polymorphic form of (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile and a method for making the polymorph. The compound is useful as a cardiotonic agent.
Inventors:
TIMMERBACKA MIKA (FI)
LEHTONEN JORMA (FI)
TANNINEN VELI PEKKA (FI)
MUTTONEN ESA (FI)
KAUKONEN JUKKA (FI)
HYPPOELAE RIIKKA (FI)
LEHTONEN JORMA (FI)
TANNINEN VELI PEKKA (FI)
MUTTONEN ESA (FI)
KAUKONEN JUKKA (FI)
HYPPOELAE RIIKKA (FI)
Application Number:
PCT/FI1997/000196
Publication Date:
January 22, 1998
Filing Date:
March 27, 1997
Export Citation:
Assignee:
ORION YHTYMAE OY (FI)
TIMMERBACKA MIKA (FI)
LEHTONEN JORMA (FI)
TANNINEN VELI PEKKA (FI)
MUTTONEN ESA (FI)
KAUKONEN JUKKA (FI)
HYPPOELAE RIIKKA (FI)
TIMMERBACKA MIKA (FI)
LEHTONEN JORMA (FI)
TANNINEN VELI PEKKA (FI)
MUTTONEN ESA (FI)
KAUKONEN JUKKA (FI)
HYPPOELAE RIIKKA (FI)
International Classes:
C07B53/00; C07B57/00; C07D237/00; C07D237/04; (IPC1-7): C07D/
Domestic Patent References:
| WO1992012135A1 | 1992-07-23 |
Foreign References:
| EP0383449A2 | 1990-08-22 | |||
| US3857889A | 1974-12-31 |
Other References:
HOWSON W ET AL: "Synthesis and biological activity of the four stereoisomers of 6-[4-[3-[[2-hydroxy-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]propyl] amino]-propionamido]phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a combined vasodilator and.beta.-adrenoceptor antagonist", J. MED. CHEM. (JMCMAR,00222623);88; VOL.31 (2); PP.352-6, SMITH KLINE AND FRENCH RES. LTD.;HERTFORDSHIRE; AL6 9AR; UK (GB), XP002047258
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