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Title:
METHOD FOR OBTAINING PURE ENANTIOMERS OF A PYRIDAZINONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO1997035841
Kind Code:
A3
Abstract:
A method for preparing optically substantially pure (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile from racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone intermediate is described. The end product is useful as a cardiotonic agent. A novel crystalline polymorphic form of the end product is also described.

Inventors:
TIMMERBACKA MIKA (FI)
LEHTONEN JORMA (FI)
TANNINEN VELI PEKKA (FI)
MUTTONEN ESA (FI)
KAUKONEN JUKKA (FI)
HYPPOELAE RIIKKA (FI)
Application Number:
FI9700196W
Publication Date:
January 22, 1998
Filing Date:
March 27, 1997
Export Citation:
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Assignee:
ORION YHTYMAE OY (FI)
TIMMERBACKA MIKA (FI)
LEHTONEN JORMA (FI)
TANNINEN VELI PEKKA (FI)
MUTTONEN ESA (FI)
KAUKONEN JUKKA (FI)
HYPPOELAE RIIKKA (FI)
International Classes:
C07B53/00; C07B57/00; C07D237/00; C07D237/04; (IPC1-7): C07D/
Domestic Patent References:
WO1992012135A11992-07-23
Foreign References:
EP0383449A21990-08-22
US3857889A1974-12-31
Other References:
HOWSON W ET AL: "Synthesis and biological activity of the four stereoisomers of 6-[4-[3-[[2-hydroxy-3-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]propyl] amino]-propionamido]phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone, a combined vasodilator and.beta.-adrenoceptor antagonist", J. MED. CHEM. (JMCMAR,00222623);88; VOL.31 (2); PP.352-6, SMITH KLINE AND FRENCH RES. LTD.;HERTFORDSHIRE; AL6 9AR; UK (GB), XP002047258
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