Title:
METHOD FOR PARALLEL SYNTHESIS AND TRANSFER OF MOLECULES TO A SUBSTRATE
Document Type and Number:
WIPO Patent Application WO2002087769
Kind Code:
A3
Abstract:
The invention relates to a method for highly parallel production of complex molecule libraries on the surface of a substrate with the aid of regeneratable matrix dies. According to prior art, the production of molecule libraries on a support is expensive, and requires a lot of time and a large amount of apparatus. By using regeneratable matrix dies it is possible to simplify and accelerate the production of molecule libraries, especially DNA and protein libraries, in a significant manner. The matrix-10 die is made of an elastic material such as polydimethylsiloxane and includes locally-bound matrix molecules on the surface thereof, said molecules being used as a model for the synthesis of copy molecules. The copy molecules are transferred to the target surface by means of a contact printing method. The matrix molecules remain on the die for further synthesis and print cycles which can repeated several times. The inventive method is suitable for copying and reproducing differently produced molecule arrays.
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Inventors:
BERNARD ANDRE (DE)
DUEBEL STEFAN (DE)
DUEBEL STEFAN (DE)
Application Number:
PCT/EP2002/004670
Publication Date:
December 31, 2003
Filing Date:
April 26, 2002
Export Citation:
Assignee:
LIFEBITS AG (DE)
BERNARD ANDRE (DE)
DUEBEL STEFAN (DE)
BERNARD ANDRE (DE)
DUEBEL STEFAN (DE)
International Classes:
B01J19/00; C07B61/00; C07K1/04; G01N33/543; C40B40/06; C40B40/10; C40B40/12; C40B50/14; C40B60/14; (IPC1-7): B01J19/00
Foreign References:
| US6096386A | 2000-08-01 | |||
| DE19543232A1 | 1997-05-15 |
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