Title:
METHOD FOR PERFORMING MITSUNOBU REACTION BETWEEN ALCOHOLIC HYDROXYL GROUP DONOR AND ACTIVE HYDROGEN DONOR
Document Type and Number:
WIPO Patent Application WO/2022/088244
Kind Code:
A1
Abstract:
A method for performing Mitsunobu reaction between an alcoholic hydroxyl group donor and an active hydrogen donor, comprising the following steps: reacting the alcoholic hydroxyl group donor and the active hydrogen donor with a trihydrocarbylphosphine reagent and an azodicarboxylate reagent in the presence of an organic solvent, wherein the organic solvent is a linear or branched alkane containing 8 to 16 carbon atoms.
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Inventors:
YE SHOUCHEN (CN)
SONG XIAOLONG (CN)
XU SHUANG (CN)
ZHAO LILIANG (CN)
SONG XIAOLONG (CN)
XU SHUANG (CN)
ZHAO LILIANG (CN)
Application Number:
PCT/CN2020/127698
Publication Date:
May 05, 2022
Filing Date:
November 10, 2020
Export Citation:
Assignee:
JIANGSU HECHENG ADVANCED MAT CO LTD (CN)
International Classes:
C07C281/02; C07C43/247; C07C69/013; C07C69/78; C07C211/35; C07C211/45; C07C321/22; C07C321/28
Domestic Patent References:
| WO2020179859A1 | 2020-09-10 |
Foreign References:
| US20050159597A1 | 2005-07-21 | |||
| CN106132422A | 2016-11-16 |
Other References:
HIROSE DAISUKE ET AL.: "Advances and mechanistic insight on the catalytic Mitsunobu reaction using recyclable azo reagents", CHEM. SCI., vol. 7, 13 April 2016 (2016-04-13), pages 5148 - 5159, XP055700657, DOI: 10.1039/C6SC00308G
SWAMY K. C. KUMARA ET AL.: "Mitsunobu and Related Reactions: Advances and Applications", CHEMICAL REVIEWS, vol. 109, no. 6, 21 April 2009 (2009-04-21), pages 2551 - 2651, XP055023394, DOI: 10.1021/cr800278z
SWAMY K. C. KUMARA ET AL.: "Mitsunobu and Related Reactions: Advances and Applications", CHEMICAL REVIEWS, vol. 109, no. 6, 21 April 2009 (2009-04-21), pages 2551 - 2651, XP055023394, DOI: 10.1021/cr800278z
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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