Title:
METHOD AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MULTIPLE SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2002/098346
Kind Code:
A3
Abstract:
Methods and pharmaceutical compositions are disclosed, effective in breaking-down immunological tolerance the CXC chemokine interferon gamma-inducible protein 10 (IP-10), resulting in the generation of self specific immunity to IP-10, for the treatment of diseases, such as autoimmune diseases, in which IP-10 plays a pivotal role in disease onset and/or progression, e.g., in multiple sclerosis (MS).
Inventors:
KARIN NATHAN (IL)
Application Number:
PCT/IL2002/000337
Publication Date:
October 31, 2013
Filing Date:
April 30, 2002
Export Citation:
Assignee:
RAPPAPORT FAMILY INST FOR RES (IL)
KARIN NATHAN (IL)
KARIN NATHAN (IL)
International Classes:
A61K48/00; A61K38/19; A61K38/22; A61K39/00; A61K39/395; A61P19/02; A61P21/04; C07K14/52; C07K14/575; C07K16/24; C07K16/26; C12N15/19; C12N15/28; C12P21/08
Foreign References:
| US6140064A | 2000-10-31 | |||
| EP0752886B1 | 1998-01-28 |
Other References:
BALASHOV ET AL.: "CCRS + and CXCR3 + T Cells are Increased in Multiple Sclerosis and their Ligands MIP-1alpha and IP-10 are Expressed in Demyelinating Brain Lesions.", PNAS USA., vol. 96, June 1999 (1999-06-01), pages 6873 - 6878
Attorney, Agent or Firm:
G.E. EHRLICH (1995) LTD. (Ramat Gan, IL)
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