Title:
METHOD FOR POLYMERIZING A SMALL OLIGONUCLEOTIDE, AND USE OF A HIGH-MOLECULAR OLIGONUCLEOTIDE PREPARED BY THE POLYMERIZATION METHOD
Document Type and Number:
WIPO Patent Application WO/2010/131835
Kind Code:
A3
Abstract:
The present invention relates to a high-molecular oligonucleotide polymerization method which increases in vivo stability, and to the use of a high-molecular oligonucleotide prepared by the polymerization method. The nucleotide polymerization method of the present invention is advantageous in that an oligonucleotide with a small molecular weight can be easily polymerized into high-molecular oligonucleotide. Further, the high-molecular oligonucleotide prepared by the method of the present invention can bind to hydrophilic high-molecular materials or inorganic materials, and then can be stably delivered to a living body. Therefore, the high-molecular oligonucleotide prepared by the method of the present invention can be widely used for treating various diseases.
Inventors:
KIM KWANG MEYUNG (KR)
KWON ICK CHAN (KR)
CHOI KUI WON (KR)
LEE SEUNG YOUNG (KR)
YOUN IN CHAN (KR)
HUH MYUNG SOOK (KR)
LEE SO JIN (KR)
KWON ICK CHAN (KR)
CHOI KUI WON (KR)
LEE SEUNG YOUNG (KR)
YOUN IN CHAN (KR)
HUH MYUNG SOOK (KR)
LEE SO JIN (KR)
Application Number:
PCT/KR2010/001296
Publication Date:
January 20, 2011
Filing Date:
March 02, 2010
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
KIM KWANG MEYUNG (KR)
KWON ICK CHAN (KR)
CHOI KUI WON (KR)
LEE SEUNG YOUNG (KR)
YOUN IN CHAN (KR)
HUH MYUNG SOOK (KR)
LEE SO JIN (KR)
KIM KWANG MEYUNG (KR)
KWON ICK CHAN (KR)
CHOI KUI WON (KR)
LEE SEUNG YOUNG (KR)
YOUN IN CHAN (KR)
HUH MYUNG SOOK (KR)
LEE SO JIN (KR)
International Classes:
C07H21/00; C12N15/87
Foreign References:
| KR100466254B1 | 2005-01-14 | |||
| KR100411234B1 | 2003-12-18 |
Other References:
URBAN-KLEIN, B. ET AL.: "RNAi-mediated gene-targeting through systemic application ofpolyethylenimin (PEI)- complexed siRNA", GENE THERAPY, vol. 12, March 2005 (2005-03-01), pages 461 - 466, XP003002818
KIM, S. H. ET AL.: "PEG conjugated VEGF siRNA for anti-angiogenic gene therapy", JOURNAL OF CONTROLLED RELEASE, vol. 116, 28 November 2006 (2006-11-28), pages 123 - 129, XP024957696, DOI: doi:10.1016/j.jconrel.2006.05.023
JEONG, J. H. ET AL.: "siRNA Conjugate Delivery Systems", BIOCONJUGATE CHEMISTRY, vol. 20, 21 January 2009 (2009-01-21), pages 5 - 14, XP002624571, DOI: doi:10.1021/bc800278e
KIM, S. H. ET AL.: "PEG conjugated VEGF siRNA for anti-angiogenic gene therapy", JOURNAL OF CONTROLLED RELEASE, vol. 116, 28 November 2006 (2006-11-28), pages 123 - 129, XP024957696, DOI: doi:10.1016/j.jconrel.2006.05.023
JEONG, J. H. ET AL.: "siRNA Conjugate Delivery Systems", BIOCONJUGATE CHEMISTRY, vol. 20, 21 January 2009 (2009-01-21), pages 5 - 14, XP002624571, DOI: doi:10.1021/bc800278e
Attorney, Agent or Firm:
PARK, Jang-Won (Shinyoung Wacoal Bldg.49-4 Nonhyun-dong, Gangnam-gu, Seoul 135-814, KR)
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