Title:
METHOD OF PREDICTING ANTICANCER DRUG RESISTANCE AND PROGNOSIS IN KIDNEY CANCER PATIENT, METHOD OF SCREENING ANTI-KIDNEY CANCER SUBSTANCE, AND PHARMACEUTICAL COMPOSITION FOR TREATING KIDNEY CANCER
Document Type and Number:
WIPO Patent Application WO/2022/071242
Kind Code:
A1
Abstract:
The present invention provides: a method of predicting the anticancer drug resistance and/or prognosis in a kidney cancer patient, said method comprising a step for evaluating the expression of Largen in the kidney cancer tissue of a subject and a step for comparing the Largen expression level in the kidney cancer tissue of the subject with a control; and a method of screening an anti-kidney cancer substance, said method comprising (1) a step for contacting a test substance with kidney cancer cells that express Largen, (2) a step for measuring the expression amount of Largen in the kidney cancer cells, and (3) a step for comparing the thus determined expression amount of Largen with the expression amount of Largen in the kidney cancer cells that have not been contacted with the test substance and thus selecting a test substance that lowers the expression amount.
Inventors:
MIYATA YASUYOSHI (JP)
YAMAMOTO KAZUO (JP)
MUKAE YUTA (JP)
SAKAI HIDEKI (JP)
YAMAMOTO KAZUO (JP)
MUKAE YUTA (JP)
SAKAI HIDEKI (JP)
Application Number:
PCT/JP2021/035438
Publication Date:
April 07, 2022
Filing Date:
September 27, 2021
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
International Classes:
A61K45/00; A61K31/7088; A61K48/00; A61P13/12; A61P15/00; A61P35/00; A61P43/00; C07K16/18; C12N15/113; C12Q1/02; C12Q1/6886; G01N33/15; G01N33/50; G01N33/53; G01N33/574; G01N33/68
Domestic Patent References:
| WO2019178283A1 | 2019-09-19 |
Foreign References:
| JP2019537108A | 2019-12-19 | |||
| JP2013512000A | 2013-04-11 | |||
| JP2020062004A | 2020-04-23 | |||
| JP2007537430A | 2007-12-20 | |||
| JP5760247B2 | 2015-08-05 |
Other References:
YAMAMOTO, KAZUO: "3. Using Nutrition for Gene Control and Vital Phenomena/Organ Function: From the Perspective of Failure and Disease, i. Molecular Basis Defining Mammal Cell Size", EXPERIMENTAL MEDICINE, vol. 34, no. 15, 1 January 2016 (2016-01-01), JP , pages 2615 - 2620, XP009535439, ISSN: 0288-5514
MIYATA YASUYOSHI, MUKAE YUTA, MATSUO TOMOHIRO, MATSUDA TSUYOSHI, HARADA JUNKI, OTSUBO ASATO, MITSUNARI KENSUKE, OHBA KOJIRO, SAKAI: "proven with recent genomic or transcriptional analyses MP39-04 LARGEN PLAYS IMPORTANT ROLES IN MALIGNANT AGGRESSIVENESS AND IS A PROGNOSTIC FACTOR IN PATIENTS WITH CLEAR CELL RENAL CELL CARCINOMA", 13 September 2021 (2021-09-13), XP055918224, Retrieved from the Internet
MIYATA YASUYOSHI, MUKAE YUTA, MATSUO TOMOHIRO, MATSUDA TSUYOSHI, HARADA JUNKI, OTSUBO ASATO, MITSUNARI KENSUKE, OHBA KOJIRO, SAKAI: "proven with recent genomic or transcriptional analyses MP39-04 LARGEN PLAYS IMPORTANT ROLES IN MALIGNANT AGGRESSIVENESS AND IS A PROGNOSTIC FACTOR IN PATIENTS WITH CLEAR CELL RENAL CELL CARCINOMA", 13 September 2021 (2021-09-13), XP055918224, Retrieved from the Internet
Attorney, Agent or Firm:
IWATANI Ryo (JP)
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