Title:
METHOD FOR PREDICTING BINDING OF BIOMOLECULE
Document Type and Number:
WIPO Patent Application WO/2019/078562
Kind Code:
A1
Abstract:
The present invention relates to a method for measuring the effective binding free energy (f
u) and standard binding free energy change (ΔG
0
bind) between a first molecule and a second molecule in an aqueous environment. The present invention also provides a method for predicting the binding of a first molecule and a second molecule in an aqueous environment through the measurement of free energy, and since the probability of binding between molecules in an aqueous environment such as an in vivo environment can be quantitatively measured with high reliability and without distortion through this method, the method can be usefully applied as a tool for screening or designing a disease treatment agent on a computer.
Inventors:
HAM SIHYUN (KR)
CHONG SEONG-HO (KR)
CHONG SEONG-HO (KR)
Application Number:
PCT/KR2018/012136
Publication Date:
April 25, 2019
Filing Date:
October 15, 2018
Export Citation:
Assignee:
UNIV SOOKMYUNG WOMENS IND ACAD COOP FOUND (KR)
International Classes:
G16C10/00; G01N33/68
Foreign References:
| JP2014186468A | 2014-10-02 | |||
| KR20160131837A | 2016-11-16 | |||
| JP2007219789A | 2007-08-30 | |||
| KR20120120023A | 2012-11-01 |
Other References:
SONG-HO CHONG: "Dynamics of Hydration Water Plays a Key Role in Determini ng the Binding Thermodynamics of Protein Complexes", SCIENTIFIC REPORTS, vol. 7, 18 August 2017 (2017-08-18), XP055595208, Retrieved from the Internet
Attorney, Agent or Firm:
KIM, Bo-min (KR)
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