METHOD FOR PREDICTING EFFICACY OF IMMUNE CHECKPOINT INHIBITORS IN CANCER PATIENTS

Title:

METHOD FOR PREDICTING EFFICACY OF IMMUNE CHECKPOINT INHIBITORS IN CANCER PATIENTS

Document Type and Number:

WIPO Patent Application WO/2018/028449

Kind Code:

A1

Abstract:

Disclosed is a method for predicting clinical response of a cancer patient to treatment with an immune checkpoint inhibitor, or a combination of two or more thereof, or with a combination of an immune checkpoint inhibitor and other antitumor drugs, by introducing bispecific T cell engager (BiTE) into the platform of lymphocytes containing T cells in vitro.

More Like This:

WO/2001/090143	POLYPEPTIDES CONTAINING POLYMORPHISMS OF THE REPEATED REGIONS OF PERTACTIN IN BORDETELLA PERTUSSIS, BORDETELLA PARAPERTUSSIS AND BORDETELLA BRONCHISEPTICA. THEIR USE IN DIAGNOSTICS, AND IN IMMUNOGENIC COMPOSITIONS
WO/2020/169537	COMBINATION OF PD-1/PD-L1 INHIBITORS AND TARGETED THORIUM CONJUGATES
JP2007531505	Techniques and compositions for the diagnosis and treatment of cancer (MUC1)

Inventors:

LUO LUSONG (CN)
DAI CHENGLIANG (CN)
SUN ZHIJIAN (CN)

Application Number:

PCT/CN2017/095144

Publication Date:

February 15, 2018

Filing Date:

July 31, 2017

Export Citation:

Click for automatic bibliography generation Help

Assignee:

BEIGENE LTD (KY)
LUO LUSONG (CN)
DAI CHENGLIANG (CN)
SUN ZHIJIAN (CN)

International Classes:

A61K39/395; A61P35/00; C07K16/00; C07K16/30

Domestic Patent References:

WO2015126548A1

2015-08-27

Foreign References:

CN105073128A

2015-11-18

Other References:

HUEHLS, A.M. ET AL.: "Bispecific T cell engagers for cancer immunotherapy", IMMUNOLOGY & - CELL BIOLOGY, vol. 93, no. 3, 31 March 2015 (2015-03-31), XP055289976
OSADA, T. ET AL.: "CEA/ CD 3-bispecific T cell -engaging (BiTE) antibody-mediated T lymphocyte cytotoxicity maximized by inhibition of both PD1 AND PD-L1", CANCER IMMUNOLOGY, IMMUNOHERAPY, vol. 64, no. 6, 6 March 2015 (2015-03-06), XP002753474
GUO, Y.J.: "Progress in monoclonal antibody-based immunotherapy for cancer treatment", CHINESE JOURNAL OF BIOTECHNOLOGY, vol. 31, no. 6, 25 June 2015 (2015-06-25), pages 857 - 870

Attorney, Agent or Firm:

WU, FENG & ZHANG CO. (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: AUTHENTICATION METHOD, DEVICE AND AUTHENTICATION CLIENT

Next Patent: LIQUID TRANSPORT SYSTEM, LINER BAG AND METHOD OF USE