METHOD FOR PREDICTING GENE TRANSFER RATE - TAKEDA PHARMACEUTICALS CO

Title:

METHOD FOR PREDICTING GENE TRANSFER RATE

Document Type and Number:

WIPO Patent Application WO/2023/190974

Kind Code:

A1

Abstract:

Disclosed is a method for predicting the gene transfer rate of animal cells, the method comprising (1) a step for measuring the cell complexity in transgenic animal cells and (2) a step for predicting the gene transfer rate on the basis of the measured value in step (1).

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Inventors:

OGAKI SOICHIRO (JP)
IIDA TOMOMINE (JP)

Application Number:

PCT/JP2023/013374

Publication Date:

October 05, 2023

Filing Date:

March 30, 2023

Export Citation:

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Assignee:

TAKEDA PHARMACEUTICALS CO (JP)

International Classes:

C12Q1/06; C12N5/0783; C12N5/10; G01N15/14; G01N33/483; G01N33/543; C12N15/09

Domestic Patent References:

WO2022045334A1

2022-03-03

Foreign References:

US20190226994A1

2019-07-25

Other References:

KOTARO HIRAMATSU, IDEGUCHI TAKURO, YONAMINE YUSUKE, LEE SANGWOOK, LUO YIZHI, HASHIMOTO KAZUKI, ITO TAKURO, HASE MISA, PARK JEE-WOO: "High-throughput label-free molecular fingerprinting flow cytometry", SCIENCE ADVANCES, vol. 5, 16 January 2019 (2019-01-16), pages eaau0241, XP055748321, DOI: 10.1126/sciadv.aau0241
WANG YONGTAO, YANG YINGJUN, YOSHITOMI TORU, KAWAZOE NAOKI, YANG YINGNAN, CHEN GUOPING: "Regulation of gene transfection by cell size, shape and elongation on micropatterned surfaces", JOURNAL OF MATERIALS CHEMISTRY. B, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 9, no. 21, 3 June 2021 (2021-06-03), GB , pages 4329 - 4339, XP093073562, ISSN: 2050-750X, DOI: 10.1039/D1TB00815C

Attorney, Agent or Firm:

SAEGUSA & PARTNERS (JP)

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