Title:
METHOD FOR PREDICTING HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2013/084504
Kind Code:
A1
Abstract:
The purpose of the present invention is to measure an s(P)RR in a living body and/or provide a method for predicting pregnancy-induced hypertension. In the present invention, it becomes possible to measure an s(P)RR in a living body by constructing a mouse monoclonal antibody using a silkworm-originated high-purity recombinant human (P)RR as an antigen. An ELISA system using the antibody of the present invention enables for the first time the measurement of an s(P)RR in a living body which cannot be measured previously, and provides an important measurement means for elucidating the relationship between an s(P)R and a disease. The present invention also relates to a method for predicting pregnancy-induced hypertension in the middle stage and the late stage of pregnancy, which comprises measuring the concentration of an s(P)RR in an early stage of pregnancy using the measurement system of the present invention.
More Like This:
| JP2001527418 | [Title of the Invention] Neurotrophic factor receptor derived from glial cell line |
| WO/2001/029256 | CEPHALIC PAIN SUSCEPTIBILITY MARKER |
| WO/2022/179466 | ANTI-SIGLEC15 ANTIBODY AND USE THEREOF |
Inventors:
ICHIHARA ATSUHIRO (JP)
MARUYAMA NOBUHIRO (JP)
SEITO TSUTOMU (JP)
MARUYAMA NOBUHIRO (JP)
SEITO TSUTOMU (JP)
Application Number:
PCT/JP2012/007845
Publication Date:
June 13, 2013
Filing Date:
December 07, 2012
Export Citation:
Assignee:
IMMUNO BIOLOGICAL LAB CO LTD (JP)
ICHIHARA ATSUHIRO (JP)
ICHIHARA ATSUHIRO (JP)
International Classes:
C07K16/28; G01N33/53; C12N15/00; C12P21/08
Foreign References:
| JP2008182905A | 2008-08-14 |
Other References:
GONZALEZ AA. ET AL.: "Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats", HYPERTENSION, vol. 7, no. 4, 5 April 2011 (2011-04-05), pages 859 - 864, XP002668817
BISWAS KB. ET AL.: "Quantitative analysis of soluble (pro) renin receptor using sandwich enzyme linked immunosorbent assay", DAI 33 KAI ANNUAL SCIENTIFIC MEETING OF THE JAPANESE SOCIETY OF HYPERTENSION, PROGRAM AND ABSTRACTS, 2010, pages 463
COUSIN C. ET AL.: "Soluble form of the (pro) renin receptor generated by intracellular cleavage by furin is secreted in plasma", HYPERTENSION, vol. 53, no. 6, 2009, pages 1077 - 1082, XP002668816
ICHIHARA A. ET AL.: "Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings", HYPERTENS. RES., vol. 33, no. 3, 2010, pages 177 - 180
NOBUHIRO MARUYAMA ET AL.: "Hito, Mouse, Rat no Kayogata (Pro) Renin Juyotai Sokuteiho no Kaihatsu", DAI 35 KAI ANNUAL SCIENTIFIC MEETING OF THE JAPANESE SOCIETY OF HYPERTENSION, PROGRAM AND ABSTRACTS, 20 September 2012 (2012-09-20)
BISWAS KB. ET AL.: "Quantitative analysis of soluble (pro) renin receptor using sandwich enzyme linked immunosorbent assay", DAI 33 KAI ANNUAL SCIENTIFIC MEETING OF THE JAPANESE SOCIETY OF HYPERTENSION, PROGRAM AND ABSTRACTS, 2010, pages 463
COUSIN C. ET AL.: "Soluble form of the (pro) renin receptor generated by intracellular cleavage by furin is secreted in plasma", HYPERTENSION, vol. 53, no. 6, 2009, pages 1077 - 1082, XP002668816
ICHIHARA A. ET AL.: "Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings", HYPERTENS. RES., vol. 33, no. 3, 2010, pages 177 - 180
NOBUHIRO MARUYAMA ET AL.: "Hito, Mouse, Rat no Kayogata (Pro) Renin Juyotai Sokuteiho no Kaihatsu", DAI 35 KAI ANNUAL SCIENTIFIC MEETING OF THE JAPANESE SOCIETY OF HYPERTENSION, PROGRAM AND ABSTRACTS, 20 September 2012 (2012-09-20)
Attorney, Agent or Firm:
HASEGAWA, Hiroshi et al. (JP)
Hiroshi Hasegawa (JP)
Hiroshi Hasegawa (JP)
Download PDF:
Claims:
Previous Patent: OPTICAL MEMBER, ULTRAVIOLET CURABLE RESIN COMPOSITION, AND CURED PRODUCT
Next Patent: DRUG SYRINGE UNIT AND DRUG INFUSION DEVICE
Next Patent: DRUG SYRINGE UNIT AND DRUG INFUSION DEVICE