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Patent Searching and Data


Title:
METHOD FOR PREDICTING ORGAN TRANSPLANT REJECTION USING NEXT-GENERATION SEQUENCING
Document Type and Number:
WIPO Patent Application WO/2016/167408
Kind Code:
A1
Abstract:
The present invention relates to a method for non-invasively predicting an organ transplant rejection by measuring the ratio between an organ-donor-specific nucleic acid sequence and a recipient-specific nucleic acid sequence in a biological sample of an organ transplant recipient and, more specifically, to a method for predicting an organ transplant rejection by measuring the ratio of a donor-derived marker sequence and a recipient-derived marker sequence regarding three or more markers selected in Tables 1 to 10 by testing a biological sample (e.g. blood) of an organ transplant recipient and predicting the organ transplant rejection based on the measurement. The method for predicting an organ transplant rejection using next-generation sequencing (NGS) according to the present invention or a digital base amplification technique can apply even to a very small amount of sample, is faster and inexpensive, is fast in the rate of data analysis, can apply to all organ transplants of all races in the word, and can simultaneously detect error probability of a sequence analysis, and thus is useful to non-invasively predict the organ transplant rejection.

Inventors:
LEE MIN SEOB (KR)
KWON SUN JAE (KR)
Application Number:
PCT/KR2015/005905
Publication Date:
October 20, 2016
Filing Date:
June 11, 2015
Export Citation:
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Assignee:
EONE DIAGNOMICS GENOME CENTER CO LTD (KR)
International Classes:
C12Q1/68; G16B30/00
Foreign References:
US20140336056A12014-11-13
KR20150035847A2015-04-07
KR20120031838A2012-04-04
KR20140024270A2014-02-28
US20110230358A12011-09-22
Other References:
See also references of EP 3285193A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
이처영 (KR)
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