Title:
METHOD FOR PREDICTING PHARMACOLOGICAL EFFECT OF NATURAL COMPOUND USING PHENOTYPE-CENTERED NETWORK ANALYSIS, AND SYSTEM THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/071621
Kind Code:
A1
Abstract:
The present invention relates to a method for predicting a pharmacological effect of a natural compound using a phenotype-centered network analysis, and a system therefor. Specifically, the method for predicting a pharmacological effect of a natural compound using a phenotype vector of a plant, according to the present invention, enables a large-scale analysis of a potential pharmacological effect of a natural compound to be conducted, not on the basis of insufficient molecular information of the natural compound, but on the basis of abundant information associated with a phenotype of a plant, and thus the method and the system therefor may be usefully employed in the development of a drug using a natural compound having a high level of safety as a result of the long-term use thereof.
Inventors:
LEE DOHEON (KR)
YOO SUNYONG (KR)
YOO SUNYONG (KR)
Application Number:
PCT/KR2019/008242
Publication Date:
April 09, 2020
Filing Date:
July 04, 2019
Export Citation:
Assignee:
BIO SYNERGY RES CENTER (KR)
KOREA ADVANCED INST SCI & TECH (KR)
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
G16B5/00; G16B40/00; G16C20/30; G16C20/50
Foreign References:
| KR101848074B1 | 2018-04-11 | |||
| KR20180086735A | 2018-08-01 | |||
| US20080138799A1 | 2008-06-12 |
Other References:
LI, Y. ET AL.: "Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network", BIOINFORMATICS, vol. 26, no. 9, 2010, pages 1219 - 1224, XP055699350
LI, S. ET AL.: "Network target for screening synergistic drug combinations with application to traditional Chinese medicine", BMC SYSTEMS BIOLOGY, vol. 5, 2011, pages 1 - 13, XP021101489
YOO, S. ET AL.: "Phenotype-oiiented network analysis for discovering pharmacological effects of natural compounds", SCIENTIFIC REPORTS, vol. 8, no. 11667, 3 August 2018 (2018-08-03), pages 1 - 9, XP055699351
LI, S. ET AL.: "Network target for screening synergistic drug combinations with application to traditional Chinese medicine", BMC SYSTEMS BIOLOGY, vol. 5, 2011, pages 1 - 13, XP021101489
YOO, S. ET AL.: "Phenotype-oiiented network analysis for discovering pharmacological effects of natural compounds", SCIENTIFIC REPORTS, vol. 8, no. 11667, 3 August 2018 (2018-08-03), pages 1 - 9, XP055699351
Attorney, Agent or Firm:
LEE, Won Hee (KR)
Download PDF: