Title:
METHOD FOR PREDICTING POST-THERAPY PROGNOSIS OF RELAPSING-REMITTING MULTIPLE SCLEROSIS (RRMS) PATIENT, AND METHOD FOR DETERMINING APPLICABILITY OF NOVEL THERAPY
Document Type and Number:
WIPO Patent Application WO/2014/200018
Kind Code:
A1
Abstract:
A therapeutic effect of the administration of interferon-β (IFN-β) on a relapsing-remitting multiple sclerosis (RRMS) patient can be predicted and an RRMS case, wherein the administration can be hardly continued because of the occurrence of a serious side effect or worsening of co-occurring immunological disorder, can be predicted by measuring the amount of plasma blasts (PB) in a sample from the RRMS patient. Further, the therapeutic effect of an IL-6 inhibitor in treating RRMS can be predicted by measuring the amount of PB in a sample from an RRMS patient, which enables the provision of a therapeutic method efficacious to a patient to whom IFN-β can be hardly applied in treating RRMS.
Inventors:
YAMAMURA TAKASHI (JP)
NAKAMURA MASAKAZU (JP)
NAKAMURA MASAKAZU (JP)
Application Number:
PCT/JP2014/065449
Publication Date:
December 18, 2014
Filing Date:
June 11, 2014
Export Citation:
Assignee:
NAT CT NEUROLOGY & PSYCHIATRY (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12Q1/06; A61K39/395; A61K45/00; A61P25/00; G01N33/50
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VICKI GLASER, SPECTRUM BIOTECHNOLOGY APPLICATIONS, 1993
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CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
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KOHLER. G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
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CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, vol. 18, 1979, pages 5294 - 5299
CHOMCZYNSKI, P ET AL., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FROHMAN, M.A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 8998 - 9002
BELYAVSKY, A. ET AL., NUCLEIC ACIDS RES., vol. 17, 1989, pages 2919 - 2932
SATO, K. ET AL., CANCER RES., vol. 53, 1993, pages 851 - 856
MULLIGAN, R.C. ET AL., NATURE, vol. 277, 1979, pages 108 - 114
MIZUSHIMA, S.; NAGATA, S., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
WARD, E.S. ET AL., NATURE, vol. 341, 1989, pages 544 - 546
WARD, E.S. ET AL., FASEB J., vol. 6, 1992, pages 2422 - 2427
BETTER, M. ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
LEI, S.P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379 - 4383
EBERT, K.M. ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
MAEDA, S. ET AL., NATURE, vol. 315, 1985, pages 592 - 594
JULIAN, K.-C. MA ET AL., EUR. J. IMMUNOL., vol. 24, 1994, pages 131 - 138
CO, M.S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M.; HORWITZ, A. H., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
PLUECKTHUN, A.; SKERRA, A., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 497 - 515
LAMOYI, E., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 66
BIRD, R. E. ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 5879 - 5883
MATSUDA, T. ET AL., EUR. J. IMMUNOL., vol. 18, 1998, pages 951 - 956
SATO K ET AL., ACADEMIC PROCEEDINGS OF THE 21ST GENERAL MEETING OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 21, 1991, pages 166
TAMURA, T. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 11924 - 11928
HIRATA, Y. ET AL., J. IMMUNOL., vol. 143, 1989, pages 2900 - 2906
VRIEND ET AL., J. MOL. GRAPHICS, vol. 8, 1990, pages 52 - 56
BRAKENHOFF ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 86 - 93
SAVINO ET AL., EMBO J., vol. 13, 1994, pages 1357 - 1367
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LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 56
WAUBANT E. ET AL.: "Clinical characteristics of responders to interferon therapy for relapsing MS", NEUROLOGY, vol. 61, 2003, pages 184 - 189, XP055316760
SHIMIZU J. ET AL.: "IFNbeta-1b may severely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum", NEUROLOGY, vol. 75, 2010, pages 1423 - 1427, XP055299200
KAKURON III: "Dai 9 Sho Shishinkei Sekizuigata Tahatsusei Kokasho", TAHATSUSEI KOKASHO CHIRYO GUIDELINE, vol. 2010, 2010, pages 104 - 109, XP008181809
NORIO CHIHARA ET AL.: "Shishinkei Sekizuien (NMO) ni Okeru Jiko Kotai Sansei Saibo", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 240, no. 6, 2012, pages 534 - 535, XP008181541
MASAKAZU NAKAMURA ET AL.: "Saihatsu Kankaigata Tahatsusei Kokasho no Byotai ni Okeru IL -6 Izonsei Plasma Blast", JAPANESE JOURNAL OF CLINICAL IMMUNOLOGY, vol. 36, no. 5, 31 October 2013 (2013-10-31), pages 345, XP008181494
J NEUROL SCI, vol. 323, no. 1-2, 2012, pages 117 - 122
PROC NATL ACAD SCI USA, vol. 108, no. 9, 2011, pages 3701 - 3706
PLOS ONE, vol. 8, no. 3, 2013, pages E57820
ANN NEUROL, vol. 47, no. 6, 2000, pages 707 - 717
N ENGL J MED, vol. 367, no. 2, 2012, pages 115 - 123
MULT SCLER, vol. 14, 2008, pages 1157 - 1174
BRAIN, vol. 120, 1997, pages 2059 - 2069
AM J NEURORADIOL, vol. 21, 2000, pages 702 - 706
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
FASEB J., vol. 6, 1992, pages 2422 - 2427
BETTER ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
LEI, S. P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379
NUCLEIC ACIDS. RES., vol. 18, no. 17, 1990, pages 5322
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
MIZUSHIMA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
VICKI GLASER, SPECTRUM BIOTECHNOLOGY APPLICATIONS, 1993
MARK, D. F. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 5662 - 6
ZOLLER, M. J.; SMITH, M., NUCLEIC ACIDS RES., vol. 10, 1982, pages 6487 - 500
WANG, A. ET AL., SCIENCE, vol. 224, 1984, pages 1431 - 3
DALBADIE-MCFARLAND, G. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409 - 13
ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC NATL ACAD SCI USA, vol. 90, 1993, pages 5873
ALTSCHUL SF ET AL., J MOL BIOL, vol. 215, 1990, pages 403
KRAMER, W.; FRITZ, H.-J.: "Oligonucleotide-directed construction of mutagenesis via gapped duplex DNA", METHODS IN ENZYMOLOGY, vol. 154, 1987, pages 350 - 367
SOUTHERN, E.M., JOURNAL OF MOLECULAR BIOLOGY, vol. 98, 1975, pages 503
SAIKI, R. K. ET AL., SCIENCE, vol. 230, 1985, pages 1350 - 1354
SAIKI, R. K. ET AL., SCIENCE, vol. 239, 1988, pages 487 - 491
YASUKAWA, K. ET AL., J. BIOCHEM., vol. 108, 1990, pages 673 - 676
EUR. J. BIOCHEM, vol. 168, 1987, pages 543 - 550
J. IMMUNOL., vol. 140, 1988, pages 1534 - 1541
AGR. BIOL. CHEM., vol. 54, 1990, pages 2685 - 2688
KEARNEY, J. F. ET AL., J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H. ET AL., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DE ST. GROTH, S. F. ET AL., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, . S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE, G. ET AL., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER. G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
BORREBAECK C.A.K.; LARRICK J. W.: "THERAPEUTIC MONOCLONAL ANTIBODIES", 1990, MACMILLAN PUBLISHERS LTD
CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, vol. 18, 1979, pages 5294 - 5299
CHOMCZYNSKI, P ET AL., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FROHMAN, M.A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 8998 - 9002
BELYAVSKY, A. ET AL., NUCLEIC ACIDS RES., vol. 17, 1989, pages 2919 - 2932
SATO, K. ET AL., CANCER RES., vol. 53, 1993, pages 851 - 856
MULLIGAN, R.C. ET AL., NATURE, vol. 277, 1979, pages 108 - 114
MIZUSHIMA, S.; NAGATA, S., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
WARD, E.S. ET AL., NATURE, vol. 341, 1989, pages 544 - 546
WARD, E.S. ET AL., FASEB J., vol. 6, 1992, pages 2422 - 2427
BETTER, M. ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
LEI, S.P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379 - 4383
EBERT, K.M. ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
MAEDA, S. ET AL., NATURE, vol. 315, 1985, pages 592 - 594
JULIAN, K.-C. MA ET AL., EUR. J. IMMUNOL., vol. 24, 1994, pages 131 - 138
CO, M.S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M.; HORWITZ, A. H., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
PLUECKTHUN, A.; SKERRA, A., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 497 - 515
LAMOYI, E., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 66
BIRD, R. E. ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 5879 - 5883
MATSUDA, T. ET AL., EUR. J. IMMUNOL., vol. 18, 1998, pages 951 - 956
SATO K ET AL., ACADEMIC PROCEEDINGS OF THE 21ST GENERAL MEETING OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 21, 1991, pages 166
TAMURA, T. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 11924 - 11928
HIRATA, Y. ET AL., J. IMMUNOL., vol. 143, 1989, pages 2900 - 2906
VRIEND ET AL., J. MOL. GRAPHICS, vol. 8, 1990, pages 52 - 56
BRAKENHOFF ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 86 - 93
SAVINO ET AL., EMBO J., vol. 13, 1994, pages 1357 - 1367
HARUAKI YAJIMA,: "Peptide Synthesis", vol. 14, 1991, HIROKAWA SHOTEN CO., LTD., article "Zoku lyakuhin no Kaihatsu"
A. OSOL: "Remington's Pharmaceutical Science, 16th edition", 1980
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 56
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Masao Haruna (JP)
Masao Haruna (JP)
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