Title:
METHOD FOR PREDICTING PROGNOSIS OF BREAST CANCER PATIENT
Document Type and Number:
WIPO Patent Application WO/2018/093236
Kind Code:
A3
Abstract:
The present invention relates to a method for predicting the prognosis of a breast cancer patient. More specifically, to provide information needed to predict the prognosis of a breast cancer patient, the method for predicting the prognosis of breast cancer including the following steps of the present invention comprises: (a) obtaining a biological sample from a breast cancer patient; (b) measuring the mRNA expression level of matrix metallopeptidase 11 (MMP11) and the mRNA expression level of cluster of differentiation 2 (CD2) from patient information or the sample of step (a); (c) normalizing the gene mRNA expression levels selected and measured in step (b); and (d) predicting the prognosis of breast cancer by combining the gene expression levels normalized in step (c), wherein overexpression of the MMP11 indicates a bad prognosis, and overexpression of CD2 indicates a good prognosis. The method of the present invention has an effect of being capable of more accurately predicting the future prognosis of metastasis, reoccurrence, or metastatic reoccurrence in a breast cancer patient, and in particular, has a very excellent ability to predict the prognosis of HER2-type breast cancer, the prognosis of which is very poor, and thus can be usefully used to provide clues for the direction of future treatment of breast cancer.
Inventors:
CHO SANG RAE (KR)
MOON YOUNG HO (KR)
HAN JIN IL (KR)
SHIN YOUNG KEE (KR)
MOON YOUNG HO (KR)
HAN JIN IL (KR)
SHIN YOUNG KEE (KR)
Application Number:
PCT/KR2017/013272
Publication Date:
August 09, 2018
Filing Date:
November 21, 2017
Export Citation:
Assignee:
GENCURIX INC (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2016004927A1 | 2016-01-14 |
Foreign References:
| US20130344482A1 | 2013-12-26 |
Other References:
GENTLES, ANDREW J.: "The prognostic landscape of genes and infiltrating immune cells across human cancers", NATURE MEDICINE, vol. 21, no. 8, 2015, pages 938 - 945, XP055534033
CHENG, CHUN-WEN: "The clinical implications of MMP-11 and CK-20 expression in human breast cancer", CLINICA CHIMICA ACTA, vol. 411, no. 3, 2010, pages 234 - 241, XP055534039
KWON, MI JEONG: "Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis", PLOS ONE, vol. 4, no. 7, 2009, pages 1 - 15, XP055534044
CHENG, CHUN-WEN: "The clinical implications of MMP-11 and CK-20 expression in human breast cancer", CLINICA CHIMICA ACTA, vol. 411, no. 3, 2010, pages 234 - 241, XP055534039
KWON, MI JEONG: "Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis", PLOS ONE, vol. 4, no. 7, 2009, pages 1 - 15, XP055534044
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
Download PDF: