Title:
METHOD FOR PREDICTING PROGNOSIS OF RHEUMATOID ARTHRITIS PATIENTS
Document Type and Number:
WIPO Patent Application WO/2008/016134
Kind Code:
A1
Abstract:
In patients treated with MRA, PIIANP decreased at week 12 from the start of the treatment compared with before the treatment, and it was found that the progression of joint destruction was suppressed in such patients, specifically, there was a correlation between the change in PIIANP at week 12 and the change in JSN at week 52. From this, it was found that by measuring PIIANP in the treatment of RA and examining its change over time in the early phase of the treatment, the prognosis of RA patients by the treatment can be predicted.
More Like This:
| JP2010517007 | Methods and biomarkers for diagnosing and monitoring psychotic disorders |
| WO/2005/052575 | MOLECULAR MARKERS OF OXIDATIVE STRESS |
| WO/2002/007747 | METHODS OF MODULATING FIBROSIS |
Inventors:
NISHIMOTO NORIHIRO (JP)
HASHIMOTO JUN (JP)
HASHIMOTO JUN (JP)
Application Number:
PCT/JP2007/065238
Publication Date:
February 07, 2008
Filing Date:
August 03, 2007
Export Citation:
Assignee:
NISHIMOTO NORIHIRO (JP)
HASHIMOTO JUN (JP)
HASHIMOTO JUN (JP)
International Classes:
G01N33/68; C07K16/24
Other References:
ROUSSEAU J.-C. ET AL.: "Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis", OSTEOARTHRITIS AND CARTILAGE, vol. 12, 2004, pages 440 - 447, XP003019913
KOBAYASHI H. ET AL.: "TNF o Chushin to shita Ko-Cytokine Ryoho", INTERNAL MEDICINE, vol. 86, no. 2, 2000, pages 285 - 290, XP003019914
MIYASAKA N.: "RA no Ko-Cytokine Ryoho", RHEUMATOLOGY, vol. 23, no. 5, 2000, pages 478 - 483, XP003019915
KOBAYASHI H. ET AL.: "TNF o Chushin to shita Ko-Cytokine Ryoho", INTERNAL MEDICINE, vol. 86, no. 2, 2000, pages 285 - 290, XP003019914
MIYASAKA N.: "RA no Ko-Cytokine Ryoho", RHEUMATOLOGY, vol. 23, no. 5, 2000, pages 478 - 483, XP003019915
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 47, JP)
Download PDF: