Title:
METHOD FOR PREDICTING PROGRESSION OF PRE-CANCEROUS LESION
Document Type and Number:
WIPO Patent Application WO/2015/119132
Kind Code:
A1
Abstract:
Disclosed is a novel means for predicting whether or not a pre-cancerous lesion of cancer such as uterine cervical cancer would be exacerbated in future. A method for predicting the progression of a pre-cancerous lesion according to the present invention comprises determining the expression of aPKCλ/τ protein in a sample separated from a subject. It is predicted that the possibility of the exacerbation of the pre-cancerous lesion is high or the possibility of the amelioration of the pre-cancerous lesion is low when the expression amount of aPKCλ/τ protein is high and/or when aPKCλ/τ protein is localized in the nucleus. It is preferred that the analysis of the expression of aPKCλ/τ protein is performed by immunostaining using an anti-aPKCλ/τ antibody or an antigen-binding fragment thereof.
Inventors:
OHNO SHIGEO (JP)
MIZUSHIMA TAICHI (JP)
HIRAHARA FUMIKI (JP)
MIYAGI ETSUKO (JP)
SATO MIKIKO (JP)
NAKAYA MASAAKI (JP)
MIZUSHIMA TAICHI (JP)
HIRAHARA FUMIKI (JP)
MIYAGI ETSUKO (JP)
SATO MIKIKO (JP)
NAKAYA MASAAKI (JP)
Application Number:
PCT/JP2015/053041
Publication Date:
August 13, 2015
Filing Date:
February 04, 2015
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY (JP)
International Classes:
G01N33/574; C12Q1/68; G01N33/48; C12N15/09
Domestic Patent References:
| WO2013039394A1 | 2013-03-21 |
Foreign References:
| JP2004505247A | 2004-02-19 | |||
| JP2012526286A | 2012-10-25 |
Other References:
TAICHI MIZUSHIMA ET AL.: "Saibo Kyokusei Seigyo Inshi atypical protein kinaseClambda/iota no Kajo Hatsugen Oyobi Kaku Kyokuzai wa Shikyukeigan no Yogo Furyo Inshi de aru", ACTA OBSTETRICA ET GYNAECOLOGIA JAPONICA, vol. 65, no. 2, 1 February 2013 (2013-02-01), pages 704
LIU XIAOJIAO ET AL.: "Disruption of precise regulation of alphaPKC expression and cellular localization is associated with cervical cancer progression", ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol. 288, no. 2, August 2013 (2013-08-01), pages 401 - 8, XP055218259, [retrieved on 20130227]
SHOICHIRO TSUGANE ET AL.: "Biomarkers in predicting cancer risk and their application for cancer prevention", CELL TECHNOLOGY, vol. 26, no. 9, 22 August 2007 (2007-08-22), pages 1009 - 1013
LIU XIAOJIAO ET AL.: "Disruption of precise regulation of alphaPKC expression and cellular localization is associated with cervical cancer progression", ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol. 288, no. 2, August 2013 (2013-08-01), pages 401 - 8, XP055218259, [retrieved on 20130227]
SHOICHIRO TSUGANE ET AL.: "Biomarkers in predicting cancer risk and their application for cancer prevention", CELL TECHNOLOGY, vol. 26, no. 9, 22 August 2007 (2007-08-22), pages 1009 - 1013
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
Patent business corporation mountain stream international patent firm (JP)
Patent business corporation mountain stream international patent firm (JP)
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