Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR PREDICTING PROGRESSION OF PRE-CANCEROUS LESION
Document Type and Number:
WIPO Patent Application WO/2015/119132
Kind Code:
A1
Abstract:
Disclosed is a novel means for predicting whether or not a pre-cancerous lesion of cancer such as uterine cervical cancer would be exacerbated in future. A method for predicting the progression of a pre-cancerous lesion according to the present invention comprises determining the expression of aPKCλ/τ protein in a sample separated from a subject. It is predicted that the possibility of the exacerbation of the pre-cancerous lesion is high or the possibility of the amelioration of the pre-cancerous lesion is low when the expression amount of aPKCλ/τ protein is high and/or when aPKCλ/τ protein is localized in the nucleus. It is preferred that the analysis of the expression of aPKCλ/τ protein is performed by immunostaining using an anti-aPKCλ/τ antibody or an antigen-binding fragment thereof.

Inventors:
OHNO SHIGEO (JP)
MIZUSHIMA TAICHI (JP)
HIRAHARA FUMIKI (JP)
MIYAGI ETSUKO (JP)
SATO MIKIKO (JP)
NAKAYA MASAAKI (JP)
Application Number:
JP2015/053041
Publication Date:
August 13, 2015
Filing Date:
February 04, 2015
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY (JP)
International Classes:
G01N33/574; C12Q1/68; G01N33/48; C12N15/09
Domestic Patent References:
WO2013039394A12013-03-21
Foreign References:
JP2004505247A2004-02-19
JP2012526286A2012-10-25
Other References:
TAICHI MIZUSHIMA ET AL.: "Saibo Kyokusei Seigyo Inshi atypical protein kinaseClambda/iota no Kajo Hatsugen Oyobi Kaku Kyokuzai wa Shikyukeigan no Yogo Furyo Inshi de aru", ACTA OBSTETRICA ET GYNAECOLOGIA JAPONICA, vol. 65, no. 2, 1 February 2013 (2013-02-01), pages 704
LIU XIAOJIAO ET AL.: "Disruption of precise regulation of alphaPKC expression and cellular localization is associated with cervical cancer progression", ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol. 288, no. 2, August 2013 (2013-08-01), pages 401 - 8, XP055218259, [retrieved on 20130227]
SHOICHIRO TSUGANE ET AL.: "Biomarkers in predicting cancer risk and their application for cancer prevention", CELL TECHNOLOGY, vol. 26, no. 9, 22 August 2007 (2007-08-22), pages 1009 - 1013
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
Patent business corporation mountain stream international patent firm (JP)
Download PDF: