Title:
METHOD FOR PREDICTING RELATIONSHIP BETWEEN GENE AND TRANSCRIPTIONAL ELEMENT AND APPARATUS THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/265323
Kind Code:
A1
Abstract:
Provided are a method for predicting relationship between a gene and a transcriptional element and an apparatus therefor. A method for predicting relationship between a gene and a transcriptional element according to some embodiments of the present disclosure may comprise the steps of: setting, as an objective function, a function for minimizing the prediction error of a mathematical model that predicts a change in the expression level of a gene on the basis of the degree of influence of the transcriptional element on the gene; and calculating a value of a determinant variable to minimize the value of the objective function by using the measurement data on the change in the expression level of the gene.
Inventors:
GU CHANGDAI (KR)
KIM YI RANG (KR)
KIM YI RANG (KR)
Application Number:
PCT/KR2022/008305
Publication Date:
December 22, 2022
Filing Date:
June 13, 2022
Export Citation:
Assignee:
ONCOCROSS CO LTD (KR)
International Classes:
G16B5/00; G16B50/00; G16H50/50
Foreign References:
| KR20160119926A | 2016-10-17 | |||
| KR100813008B1 | 2008-03-13 | |||
| KR20070061107A | 2007-06-13 | |||
| KR20160023137A | 2016-03-03 |
Other References:
SHI WENQIANG, FORNES ORIOL, WASSERMAN WYETH W: "Gene expression models based on transcription factor binding events confer insight into functional cis-regulatory variants", BIOINFORMATICS, OXFORD UNIVERSITY PRESS , SURREY, GB, vol. 35, no. 15, 1 August 2019 (2019-08-01), GB , pages 2610 - 2617, XP093015365, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty992
Attorney, Agent or Firm:
LIM, Hyung Chul et al. (KR)
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