Title:
METHOD FOR PREDICTING RESPONSE TO ANTICANCER IMMUNOTHERAPEUTIC AGENTS
Document Type and Number:
WIPO Patent Application WO/2024/091053
Kind Code:
A1
Abstract:
The present invention relates to a method for predicting the response to immunotherapeutic agents, comprising a step of measuring, in cancer cells or cancer tissue, the expression level of a dexamethasone-induced ras-related protein 1 (Dexras 1) gene or a protein encoded thereby. According to the present invention, research has been carried for prediction of the response to immunotherapeutic agents and, particularly, research has been carried out for prediction of the response to immunotherapeutic agents, highly reliable therapeutic agents and effective diagnosis of stem cell-like gastric cancer, which has the poorest prognosis and for which discovery of an effective treatment and diagnosis is difficult. As a result, it has been identified that in refractory carcinoma, the expression of Dexras 1 is high and, when an immunotherapeutic agent is injected, resistance to the immunotherapeutic agent is exhibited. In addition, changes in the expression level of Dexras 1 in cancer samples are measured such that immunotherapeutic agents for refractory cancer, such as stem cell-like gastric cancer that is difficult to be treated, are provided and refractory cancer can be diagnosed, and the response to anticancer immunotherapeutic agents for effective immunotherapy can be predicted such that the present invention has been completed. Therefore, the present invention is expected to be widely used in the development of novel therapeutic agents for refractory cancer.
Inventors:
KIM JAE-WOO (KR)
CHEONG JAE-HO (KR)
FANG SUNGSOON (KR)
YOON BO KYUNG (KR)
CHUN KYU-HYE (KR)
CHEONG JAE-HO (KR)
FANG SUNGSOON (KR)
YOON BO KYUNG (KR)
CHUN KYU-HYE (KR)
Application Number:
PCT/KR2023/016825
Publication Date:
May 02, 2024
Filing Date:
October 27, 2023
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
C12Q1/6886; A01K67/027; C12N15/85; G01N33/574
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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