Title:
METHOD FOR PREDICTING SENSITIVITY OF CANCER CELL TO GPX4 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/132592
Kind Code:
A1
Abstract:
A therapeutic agent for cancer that comprises a GPX4-inhibiting compound as an active ingredient and contains a cancer cell in which depression of the function of SWI/SNF complex is detected, and a method for predicting the sensitivity of a cancer cell to a GPX4 inhibitor, said method comprising a step for predicting a cancer cell, in which depression of the function of SWI/SNF complex is detected, as having sensitivity to the GPX4 inhibitor.
Inventors:
OGASAWARA KIYOMOTO (JP)
HASHIMOTO KEISUKE (JP)
KASHIMA KENJI (JP)
SAKAMOTO HIROSHI (JP)
HASHIMOTO KEISUKE (JP)
KASHIMA KENJI (JP)
SAKAMOTO HIROSHI (JP)
Application Number:
PCT/JP2020/048811
Publication Date:
July 01, 2021
Filing Date:
December 25, 2020
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K45/00; A61K31/437; A61K31/496; A61P35/00; A61P43/00; C12N5/09; C12N9/99; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/574
Domestic Patent References:
| WO1994011523A2 | 1994-05-26 |
Other References:
ZOU, Y. ET AL.: "A GPX4-dependent cancer cell state underlies the clear- cell morphology and confers sensitivity to ferroptosis", NAT COMMUN, vol. 10, no. 1617, 8 April 2019 (2019-04-08), pages 1 - 13, XP055798511, ISSN: 2041-1723
OGIWARA, H. ET AL.: "Targeting the Vulnerability of Glutathione Metabolism in ARIDIA-Deficient Cancers", CANCER CELL, vol. 35, 11 February 2019 (2019-02-11), pages 177 - 90, XP085598939, ISSN: 1535-6108
MAKOTO MAEMONDO ET AL., NEJM, vol. 362, no. 25, 24 June 2010 (2010-06-24), pages 2380 - 2388
PAUL B. CHAPMAN ET AL., NEJM, vol. 364, no. 26, 30 June 2011 (2011-06-30), pages 2507 - 2516
D. ROSS CAMIDGE ET AL., J THORAC ONCOL, vol. 14, no. 7, July 2019 (2019-07-01), pages 1233 - 1243
YIBO XUE ET AL.: "10", NAT. COMMUN., 2019, pages 557
YONATHAN LISSANU DERIBE ET AL., NAT. MED., vol. 24, July 2018 (2018-07-01), pages 1047 - 1057
VURAL TAGAL ET AL., NAT. COMMUN., vol. 8, 2017, pages 14098
HIDEAKI OGIWARA ET AL., CANCER CELL, vol. 35, 2019, pages 177 - 190
VISWANATHAN ET AL., NATURE, vol. 547, no. 7664, 27 July 2017 (2017-07-27), pages 453 - 457
YANG ET AL., CELL, vol. 156, no. 0, 16 January 2014 (2014-01-16), pages 317 - 331
SHINOME ET AL.: "22", ANTIOXID. REDOX SIGNAL., no. 4, pages 281 - 293
MICHAEL L. PHELAN ET AL., MOLECULAR CELL, vol. 3, February 1999 (1999-02-01), pages 247 - 253
BROAD INSTITUTE: ''CANCER CELL LINE ENCYCLOPEDIA, Retrieved from the Internet
HOFFMAN ET AL., PNAS FEBRUARY, vol. 25, no. 8, 2014, pages 3128 - 3133
MATSUBARA ET AL., CANCER SCI, vol. 104, no. 2, February 2013 (2013-02-01), pages 266 - 273
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495
P. J. DELVES: "Antibody Production: Essential Techniques", 1997, WILEY
P. SHEPHERDC. DEAN: "Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
VANDAMME AM ET AL.: "Eur. J. Biochem.", vol. 192, 1990, pages: 767 - 775
INT J CANCER, vol. 118, 2006, pages 1992 - 7
See also references of EP 4082575A4
OGIWARA, H. ET AL.: "Targeting the Vulnerability of Glutathione Metabolism in ARIDIA-Deficient Cancers", CANCER CELL, vol. 35, 11 February 2019 (2019-02-11), pages 177 - 90, XP085598939, ISSN: 1535-6108
MAKOTO MAEMONDO ET AL., NEJM, vol. 362, no. 25, 24 June 2010 (2010-06-24), pages 2380 - 2388
PAUL B. CHAPMAN ET AL., NEJM, vol. 364, no. 26, 30 June 2011 (2011-06-30), pages 2507 - 2516
D. ROSS CAMIDGE ET AL., J THORAC ONCOL, vol. 14, no. 7, July 2019 (2019-07-01), pages 1233 - 1243
YIBO XUE ET AL.: "10", NAT. COMMUN., 2019, pages 557
YONATHAN LISSANU DERIBE ET AL., NAT. MED., vol. 24, July 2018 (2018-07-01), pages 1047 - 1057
VURAL TAGAL ET AL., NAT. COMMUN., vol. 8, 2017, pages 14098
HIDEAKI OGIWARA ET AL., CANCER CELL, vol. 35, 2019, pages 177 - 190
VISWANATHAN ET AL., NATURE, vol. 547, no. 7664, 27 July 2017 (2017-07-27), pages 453 - 457
YANG ET AL., CELL, vol. 156, no. 0, 16 January 2014 (2014-01-16), pages 317 - 331
SHINOME ET AL.: "22", ANTIOXID. REDOX SIGNAL., no. 4, pages 281 - 293
MICHAEL L. PHELAN ET AL., MOLECULAR CELL, vol. 3, February 1999 (1999-02-01), pages 247 - 253
BROAD INSTITUTE: ''CANCER CELL LINE ENCYCLOPEDIA, Retrieved from the Internet
HOFFMAN ET AL., PNAS FEBRUARY, vol. 25, no. 8, 2014, pages 3128 - 3133
MATSUBARA ET AL., CANCER SCI, vol. 104, no. 2, February 2013 (2013-02-01), pages 266 - 273
KOHLERMILSTEIN, NATURE, vol. 256, 1975, pages 495
P. J. DELVES: "Antibody Production: Essential Techniques", 1997, WILEY
P. SHEPHERDC. DEAN: "Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
VANDAMME AM ET AL.: "Eur. J. Biochem.", vol. 192, 1990, pages: 767 - 775
INT J CANCER, vol. 118, 2006, pages 1992 - 7
See also references of EP 4082575A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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