Title:
METHOD FOR PREDICTING THERAPEUTIC EFFECT OF COMBINATION CHEMOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2010/074241
Kind Code:
A1
Abstract:
Disclosed is an anti-tumor agent which can exhibit a superior life-prolonging effect on progressive gastric cancer patients, on whom conventional therapy methods cannot exhibit a satisfactory life-prolonging effect, compared to those of the conventional therapy methods, when the patients are selected by employing a thymidylate synthase as a measure. The anti-tumor agent comprises a tegafur-gimeracil-(oteracil potassium) combination preparation and cisplatin.
Inventors:
OKA TOSHINORI (JP)
Application Number:
PCT/JP2009/071626
Publication Date:
July 01, 2010
Filing Date:
December 25, 2009
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
OKA TOSHINORI (JP)
OKA TOSHINORI (JP)
International Classes:
C12Q1/68; A61K31/44; A61K31/513; A61K31/53; A61K33/243; A61P35/00; C12N15/09
Other References:
KOIZUMI, W. ET AL.: "S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial.", LANCET ONCOLOGY, vol. 9, 18 February 2008 (2008-02-18), pages 215 - 221
SHIROTA, Y. ET AL.: "ERCC1 and Thymidylate Synthase mRNA Levels Predict Survival for Colorectal Cancer Patients Receiving Combination Oxaliplatin and Fluorouracil Chemotherapy.", JOURNAL OF CLINICAL ONCOLOGY, vol. 19, no. 23, 2001, pages 4298 - 4304
NORIKO YAMAMOTO ET AL.: "Shinko Igan ni Taisuru Jutsumae Kagaku Ryoho (TS-1+CDDP) no Koka Yosoku Maker no Kento", DAI 67 KAI NIHON GAN GAKKAI GAKUJUTSU SOKAI KIJI, 30 September 2008 (2008-09-30), pages 74
YOICHI SAKURAI ET AL.: "Kagaku Ryoho no Koka Yosoku-Yogo Yosoku Koka Yosoku-Yogo Yosoku OPRT, TS, p53 no Hatsugen to Kagaku Ryoho no Koka Yosoku", IGAN -KISO-RINSHO KENKYU NO UPDATE-, JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 66, no. ISS.5, 28 July 2008 (2008-07-28), pages 518 - 522
KAMOSHIDA, S. ET AL.: "Immunostaining of thymidylate synthase and p53 for predicting chemoresistance to S-1/cisplatin in gastric cancer.", BRITISH JOURNAL OF CANCER, vol. 96, no. 2, 2007, pages 277 - 283
NOBUHIRO KURITA ET AL.: "Shinko Saihatsu Igan ni Taisuru Kagaku Ryoho ni Okeru Yogo Yosoku Inshi no Kento", DAI 49 KAI NIPPON SHOKAKIBYO GAKKAI TAIKAI SHOROKUSHU, JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 104, 20 September 2007 (2007-09-20), pages A602
WEI, J. ET AL.: "ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimen.", BRITISH JOURNAL OF CANCER, vol. 98, no. 8, 25 March 2008 (2008-03-25), pages 1398 - 1402
YOSHIDA, K. ET AL.: "Challenge for a better combination with basic evidence.", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 13, no. 3, June 2008 (2008-06-01), pages 212 - 219
SHIROTA, Y. ET AL.: "ERCC1 and Thymidylate Synthase mRNA Levels Predict Survival for Colorectal Cancer Patients Receiving Combination Oxaliplatin and Fluorouracil Chemotherapy.", JOURNAL OF CLINICAL ONCOLOGY, vol. 19, no. 23, 2001, pages 4298 - 4304
NORIKO YAMAMOTO ET AL.: "Shinko Igan ni Taisuru Jutsumae Kagaku Ryoho (TS-1+CDDP) no Koka Yosoku Maker no Kento", DAI 67 KAI NIHON GAN GAKKAI GAKUJUTSU SOKAI KIJI, 30 September 2008 (2008-09-30), pages 74
YOICHI SAKURAI ET AL.: "Kagaku Ryoho no Koka Yosoku-Yogo Yosoku Koka Yosoku-Yogo Yosoku OPRT, TS, p53 no Hatsugen to Kagaku Ryoho no Koka Yosoku", IGAN -KISO-RINSHO KENKYU NO UPDATE-, JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 66, no. ISS.5, 28 July 2008 (2008-07-28), pages 518 - 522
KAMOSHIDA, S. ET AL.: "Immunostaining of thymidylate synthase and p53 for predicting chemoresistance to S-1/cisplatin in gastric cancer.", BRITISH JOURNAL OF CANCER, vol. 96, no. 2, 2007, pages 277 - 283
NOBUHIRO KURITA ET AL.: "Shinko Saihatsu Igan ni Taisuru Kagaku Ryoho ni Okeru Yogo Yosoku Inshi no Kento", DAI 49 KAI NIPPON SHOKAKIBYO GAKKAI TAIKAI SHOROKUSHU, JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 104, 20 September 2007 (2007-09-20), pages A602
WEI, J. ET AL.: "ERCC1 mRNA levels and survival of advanced gastric cancer patients treated with a modified FOLFOX regimen.", BRITISH JOURNAL OF CANCER, vol. 98, no. 8, 25 March 2008 (2008-03-25), pages 1398 - 1402
YOSHIDA, K. ET AL.: "Challenge for a better combination with basic evidence.", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 13, no. 3, June 2008 (2008-06-01), pages 212 - 219
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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