Title:
METHOD FOR PREDICTING VASCULAR AGING, METHOD FOR PREDICTING DISEASE RISK, BIOMARKER FOR PREDICTING VASCULAR AGING, BIOMARKER FOR DISEASES, MEASUREMENT KIT, AND DIAGNOSTIC DEVICE
Document Type and Number:
WIPO Patent Application WO/2021/085425
Kind Code:
A1
Abstract:
Provided are: a biomarker which can be used in the diagnosis of vascular aging in a subject and is included in a biological sample taken from the subject; and a method and a biomarker for not only evaluating the degree of progression of vascular aging in the subject by measuring an expression level of the biomarker but also determining the presence or absence of arteriosclerotic disease, cerebrovascular disease, cardiovascular disease, or other aging-related diseases of the subject. The gene expression level of one or both of CMPK2 and RNF213, which are contained in the biological sample taken from the subject as a biomarker for predicting vascular aging, are measured. In addition, the gene expression level of one or both of CMPK2 and RNF213, which are contained in the biological sample taken from the subject as a biomarker for arteriosclerotic disease, cerebrovascular disease, or cardiovascular disease, are measured. Saliva can be suitably used as a biological sample taken from a subject.
Inventors:
HONDA YOSHITOMO (JP)
KAWAMOTO AKIYO (JP)
TAKAHASHI KAZUYA (JP)
SHIMIZU HIDEO (JP)
UEDA MAMORU (JP)
NINOMIYA YUICHI (JP)
KAWAZOE TAKAYOSHI (JP)
HAMADA YOSHIHIRO (JP)
KAWAMOTO AKIYO (JP)
TAKAHASHI KAZUYA (JP)
SHIMIZU HIDEO (JP)
UEDA MAMORU (JP)
NINOMIYA YUICHI (JP)
KAWAZOE TAKAYOSHI (JP)
HAMADA YOSHIHIRO (JP)
Application Number:
PCT/JP2020/040285
Publication Date:
May 06, 2021
Filing Date:
October 27, 2020
Export Citation:
Assignee:
HONDA YOSHITOMO (JP)
KAWAMOTO AKIYO (JP)
TAKAHASHI KAZUYA (JP)
SHIMIZU HIDEO (JP)
UEDA MAMORU (JP)
Y OCEAN CO LTD (JP)
NINOMIYA YUICHI (JP)
KAWAZOE TAKAYOSHI (JP)
KAWAMOTO AKIYO (JP)
TAKAHASHI KAZUYA (JP)
SHIMIZU HIDEO (JP)
UEDA MAMORU (JP)
Y OCEAN CO LTD (JP)
NINOMIYA YUICHI (JP)
KAWAZOE TAKAYOSHI (JP)
International Classes:
C12M1/34; C12N15/12; C12N15/54; C12Q1/6851; C12Q1/686; C12Q1/6876; G01N33/50
Domestic Patent References:
| WO2011144818A1 | 2011-11-24 | |||
| WO2020121489A1 | 2020-06-18 |
Foreign References:
| JP2014519487A | 2014-08-14 | |||
| KR20180047774A | 2018-05-10 | |||
| JP2018143178A | 2018-09-20 | |||
| JP2020092660A | 2020-06-18 |
Other References:
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LIU, W. ET AL.: "Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development", PLOS ONE, vol. 6, no. 7, 2011, pages e22542, XP055657048, DOI: 10.1371/journal.pone.0022542
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CHUNG HAE YOUNG, KIM DAE HYUN, LEE EUN KYEONG, CHUNG KI WUNG, CHUNG SANGWOON, LEE BONGGI, SEO ARNOLD Y., CHUNG JAE HEUN, JUNG YOUN: "Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept", AGING DIS., vol. 10, no. 2, 2019, pages 367 - 382, XP055821672
ANDRÉS LAGUNA-FERNÁNDEZ, SUSANA NOVELLA, CARLOS BUENO-BETÍ, JAUME MARRUGAT , CARLOS: "Endothelial transcriptomic changes induced by oxidized low density lipoprotein disclose an up-regulation of Jak-Stat pathway", VASCUL. PHARMACOL., vol. 73, 2015, pages 104 - 114, XP055821679
LAGERSTEDT LINNEA; JOSE EGEA-GUERRERO JUAN; BUSTAMANTE ALEJANDRO; MONTANER JOAN; RODRIGUEZ-RODRIGUEZ ANA; EL RAHAL AMIR; TURCK NAT: "Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease", PLOS ONE, vol. 12, no. 4, 2017, pages e0175649, XP009506579
YOSHIHIRO HAMADA, YOSHITOMO HONDA , AKIYO KAWAMOTO , HIDEO SHIMIZU AND KAZUYA TAKAHASHI: "Detection of biomarkers on aging and vascular senescence in saliva", J. OSAKA DENT. UNIV., vol. 54, no. 1, 2020, pages 117 - 125, XP055821684
FÁBRYOVÁ H, CELEC P: "On the origin and diagnostic use of salivary RNA", ORAL DISEASES, vol. 20, 2014, pages 146 - 152, XP055821691
BOREL NICOLE; MUKHOPADHYAY SANGHAMITRA; KAISER CARMEN; SULLIVAN ERIN D; MILLER RICHARD D; TIMMS PETER; SUMMERSGILL JAMES T; RAMIRE: "Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection", BMC INFECT. DIS., vol. 6, no. 152, 2006, pages 1 - 8, XP021022856
SATO-MAEDA, M. ET AL.: "Transient middle cerebral artery occlusion in mice induces neuronal expression of RNF213, a susceptibility gene for moyamoya disease", BRAIN RES., vol. 1630, 10 November 2015 (2015-11-10), pages 50 - 55, XP029339818, DOI: 10.1016/j.brainres.2015.10.055
MAEDA, MIKA ET AL.: "Analysis of transcript variant expression dynamics of Moyamoya disease susceptibility gene Rnf213, using ischemia brain model of rat", PROGRAMS AND ABSTRACTS OF THE CONFERENCE OF THE JAPAN SOCIETY OF MOLECULAR NEUROSURGERY, vol. 17, 2016, pages 73
ZHANG SHUYI, KIM CHARLES C., BATRA SAJEEV, MCKERROW JAMES H., LOKE P'NG: "Delineation of Diverse Macrophage Activation Programs in Response to Intracellular Parasites and Cytokines", PLOS NEGL. TROP. DIS., vol. 4, no. 3, 2010, pages e648, XP055821698
KURE, SHIGEO: "Functional analysis of Moyamoya disease susceptibility gene RNF213", RESEARCH REPORTS OF THE UEHARA MEMORIAL FOUNDATION, vol. 27, no. 137, 2013, pages 1 - 4
FUMIAKI KAMADA 1, YOKO AOKI, AYUMI NARISAWA, YU ABE, SHOKO KOMATSUZAKI, ATSUO KIKUCHI, JUNKO KANNO, TETSUYA NIIHORI, MASAO ONO, NA: "A genome-wide association study identifies RNF213 as the first Moyamoya disease gene", J. HUM. GENET., vol. 56, 2011, pages 34 - 40, XP055821662
LIU, W. ET AL.: "Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development", PLOS ONE, vol. 6, no. 7, 2011, pages e22542, XP055657048, DOI: 10.1371/journal.pone.0022542
KAZUHIRO OHKUBO, YASUNARI SAKAI, HIROSUKE INOUE, SATOSHI AKAMINE, YOSHITO ISHIZAKI, YUKI MATSUSHITA, MASAFUMI SANEFUJI, HIROYUKI T: "Moyamoya disease susceptibility gene RNF213 links inflammatory and angiogenic signals in endothelial cells", SCI. REP., vol. 5, no. 13191, 2015, pages 1 - 14, XP055821668
CHUNG HAE YOUNG, KIM DAE HYUN, LEE EUN KYEONG, CHUNG KI WUNG, CHUNG SANGWOON, LEE BONGGI, SEO ARNOLD Y., CHUNG JAE HEUN, JUNG YOUN: "Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept", AGING DIS., vol. 10, no. 2, 2019, pages 367 - 382, XP055821672
ANDRÉS LAGUNA-FERNÁNDEZ, SUSANA NOVELLA, CARLOS BUENO-BETÍ, JAUME MARRUGAT , CARLOS: "Endothelial transcriptomic changes induced by oxidized low density lipoprotein disclose an up-regulation of Jak-Stat pathway", VASCUL. PHARMACOL., vol. 73, 2015, pages 104 - 114, XP055821679
LAGERSTEDT LINNEA; JOSE EGEA-GUERRERO JUAN; BUSTAMANTE ALEJANDRO; MONTANER JOAN; RODRIGUEZ-RODRIGUEZ ANA; EL RAHAL AMIR; TURCK NAT: "Significant association of RNF213 p.R4810K, a moyamoya susceptibility variant, with coronary artery disease", PLOS ONE, vol. 12, no. 4, 2017, pages e0175649, XP009506579
YOSHIHIRO HAMADA, YOSHITOMO HONDA , AKIYO KAWAMOTO , HIDEO SHIMIZU AND KAZUYA TAKAHASHI: "Detection of biomarkers on aging and vascular senescence in saliva", J. OSAKA DENT. UNIV., vol. 54, no. 1, 2020, pages 117 - 125, XP055821684
FÁBRYOVÁ H, CELEC P: "On the origin and diagnostic use of salivary RNA", ORAL DISEASES, vol. 20, 2014, pages 146 - 152, XP055821691
BOREL NICOLE; MUKHOPADHYAY SANGHAMITRA; KAISER CARMEN; SULLIVAN ERIN D; MILLER RICHARD D; TIMMS PETER; SUMMERSGILL JAMES T; RAMIRE: "Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection", BMC INFECT. DIS., vol. 6, no. 152, 2006, pages 1 - 8, XP021022856
SATO-MAEDA, M. ET AL.: "Transient middle cerebral artery occlusion in mice induces neuronal expression of RNF213, a susceptibility gene for moyamoya disease", BRAIN RES., vol. 1630, 10 November 2015 (2015-11-10), pages 50 - 55, XP029339818, DOI: 10.1016/j.brainres.2015.10.055
MAEDA, MIKA ET AL.: "Analysis of transcript variant expression dynamics of Moyamoya disease susceptibility gene Rnf213, using ischemia brain model of rat", PROGRAMS AND ABSTRACTS OF THE CONFERENCE OF THE JAPAN SOCIETY OF MOLECULAR NEUROSURGERY, vol. 17, 2016, pages 73
ZHANG SHUYI, KIM CHARLES C., BATRA SAJEEV, MCKERROW JAMES H., LOKE P'NG: "Delineation of Diverse Macrophage Activation Programs in Response to Intracellular Parasites and Cytokines", PLOS NEGL. TROP. DIS., vol. 4, no. 3, 2010, pages e648, XP055821698
KURE, SHIGEO: "Functional analysis of Moyamoya disease susceptibility gene RNF213", RESEARCH REPORTS OF THE UEHARA MEMORIAL FOUNDATION, vol. 27, no. 137, 2013, pages 1 - 4
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THE PATENT CORPORATE BODY GLOBAL INTELLECTUAL PROPERTY (JP)
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