Title:
METHOD OF PREDICTION OF GESTATIONAL DIABETES MELLITUS BASED ON THE EXPRESSION PROFILE OF CARDIOVASCULAR MIRNAS
Document Type and Number:
WIPO Patent Application WO/2024/032834
Kind Code:
A1
Abstract:
Method of prediction of gestational diabetes mellitus including both its milder and more severe form. Pregnant women are screened to determine the expression profile of two or more miRNAs in whole peripheral venous blood collected in the period of 10th–13th gestational week, whereas said two or more miRNAs are selected from the group miR-1-3p, miR-20a-5p, miR-20b-5p, miR-23a-3p, miR-100-5p, miR-125b-5p, miR-126-3p, miR-181a-5p, miR-195-5p, miR-499a-5p, and miR-574-3p.
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Inventors:
HROMADNIKOVA ILONA (CZ)
Application Number:
PCT/CZ2023/050047
Publication Date:
February 15, 2024
Filing Date:
August 03, 2023
Export Citation:
Assignee:
GENESPECTOR S R O (CZ)
International Classes:
C12Q1/6883
Other References:
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YANG HAIOU ET AL: "Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 18, no. 1, 22 January 2020 (2020-01-22), XP093093546, Retrieved from the Internet DOI: 10.1186/s12967-020-02227-w
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ZHU YANAN ET AL: "Profiling maternal plasma microRNA expression in early pregnancy to predict gestational diabetes mellitus", INTERNATIONAL JOURNAL OF GYNECOLOGY AND OBSTETRICS, NEW YORK, NY, US, vol. 130, no. 1, 23 March 2015 (2015-03-23), pages 49 - 53, XP029172421, ISSN: 0020-7292, DOI: 10.1016/J.IJGO.2015.01.010
HROMADNIKOVA ILONA ET AL: "Cardiovascular Disease-Associated MicroRNAs as Novel Biomarkers of First-Trimester Screening for Gestational Diabetes Mellitus in the Absence of Other Pregnancy-Related Complications", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, no. 18, 13 September 2022 (2022-09-13), pages 10635, XP093093709, Retrieved from the Internet DOI: 10.3390/ijms231810635
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SWEETING ET AL., FETAL DIAGN. THER., vol. 45, 2019, pages 76 - 84
WANG ET AL., DIABETES RES. CLIN. PRACT., vol. 142, 2018, pages 130 - 138
SAKURAI ET AL., J. DIABETES INVESTIG., vol. 10, 2019, pages 513 - 520
TENENBAUM-GAVISH ET AL., PLACENTA, vol. 101, 2020, pages 80 - 89
ZHENG ET AL., FRONT. PUBLIC HEALTH, vol. 10, 2022, pages 850191
ZHANG ET AL., EXP. THER. MED., vol. 20, 2020, pages 293 - 300
CREMONA ET AL., CLIN. NUTR. ESPEN, vol. 45, 2021, pages 312 - 321
SHAARBAF EIDGAHI ET AL., BMC PREGNANCY CHILDBIRTH, vol. 22, 2022, pages 13
LAMADRID-ROMERO ET AL., NEUROSCI. RES., vol. 130, 2018, pages 8 - 22
THAMOTHARAN ET AL., PLOS ONE, vol. 17, no. 5, 2022, pages e0267564
YOFFE ET AL., EUR. J. ENDOCRINOL., vol. 181, 2019, pages 565 - 577
LEGARE ET AL., BMJ OPEN DIABETES RES. CARE, vol. 10, 2022, pages e002703
CAO ET AL., J. OBSTET. GYNAECOL. RES., vol. 43, 2017, pages 974 - 981
SPRENSEN ET AL., CELLS, vol. 10, 2021, pages 170
ZHAO ET AL., PLOS ONE, vol. 6, 2011, pages e23925
HROMADNIKOVA ET AL., INT. J. MOL. SCI., vol. 21, 2020, pages 2437
HROMADNIKOVA ET AL., BIOMEDICINES, vol. 10, 2022, pages 718
HROMADNIKOVA ET AL., INT. J. MOL. SCI., vol. 23, 2022, pages 3951
FOYE CATHERINE ET AL: "Comparison of miRNA quantitation by Nanostring in serum and plasma samples", PLOS ONE, vol. 12, no. 12, 6 December 2017 (2017-12-06), pages e0189165, XP093095377, Retrieved from the Internet
YANG HAIOU ET AL: "Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 18, no. 1, 22 January 2020 (2020-01-22), XP093093546, Retrieved from the Internet
SADEGHI SAMIRA ET AL: "Nanostructures in non-invasive prenatal genetic screening", BIOMEDICAL ENGINEERING LETTERS, THE KOREAN SOCIETY OF MEDICAL AND BIOLOGICAL ENGINEERING, KOREA, vol. 12, no. 1, 11 October 2021 (2021-10-11), pages 3 - 18, XP037686516, ISSN: 2093-9868, [retrieved on 20211011], DOI: 10.1007/S13534-021-00208-6
MASETE MATLADI ET AL: "A Big Role for microRNAs in Gestational Diabetes Mellitus", FRONTIERS IN ENDOCRINOLOGY, vol. 13, 25 July 2022 (2022-07-25), CH, XP093097275, ISSN: 1664-2392, DOI: 10.3389/fendo.2022.892587
ZHU YANAN ET AL: "Profiling maternal plasma microRNA expression in early pregnancy to predict gestational diabetes mellitus", INTERNATIONAL JOURNAL OF GYNECOLOGY AND OBSTETRICS, NEW YORK, NY, US, vol. 130, no. 1, 23 March 2015 (2015-03-23), pages 49 - 53, XP029172421, ISSN: 0020-7292, DOI: 10.1016/J.IJGO.2015.01.010
HROMADNIKOVA ILONA ET AL: "Cardiovascular Disease-Associated MicroRNAs as Novel Biomarkers of First-Trimester Screening for Gestational Diabetes Mellitus in the Absence of Other Pregnancy-Related Complications", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 23, no. 18, 13 September 2022 (2022-09-13), pages 10635, XP093093709, Retrieved from the Internet
SYNGELAKI ET AL., FETAL. DIAGN. THER., vol. 38, 2015, pages 14 - 21
SWEETING ET AL., DIABETES RES. CLIN. PRACT., vol. 127, 2017, pages 44 - 50
SWEETING ET AL., FETAL DIAGN. THER., vol. 45, 2019, pages 76 - 84
WANG ET AL., DIABETES RES. CLIN. PRACT., vol. 142, 2018, pages 130 - 138
SAKURAI ET AL., J. DIABETES INVESTIG., vol. 10, 2019, pages 513 - 520
TENENBAUM-GAVISH ET AL., PLACENTA, vol. 101, 2020, pages 80 - 89
ZHENG ET AL., FRONT. PUBLIC HEALTH, vol. 10, 2022, pages 850191
ZHANG ET AL., EXP. THER. MED., vol. 20, 2020, pages 293 - 300
CREMONA ET AL., CLIN. NUTR. ESPEN, vol. 45, 2021, pages 312 - 321
SHAARBAF EIDGAHI ET AL., BMC PREGNANCY CHILDBIRTH, vol. 22, 2022, pages 13
LAMADRID-ROMERO ET AL., NEUROSCI. RES., vol. 130, 2018, pages 8 - 22
THAMOTHARAN ET AL., PLOS ONE, vol. 17, no. 5, 2022, pages e0267564
YOFFE ET AL., EUR. J. ENDOCRINOL., vol. 181, 2019, pages 565 - 577
LEGARE ET AL., BMJ OPEN DIABETES RES. CARE, vol. 10, 2022, pages e002703
CAO ET AL., J. OBSTET. GYNAECOL. RES., vol. 43, 2017, pages 974 - 981
SPRENSEN ET AL., CELLS, vol. 10, 2021, pages 170
ZHAO ET AL., PLOS ONE, vol. 6, 2011, pages e23925
HROMADNIKOVA ET AL., INT. J. MOL. SCI., vol. 21, 2020, pages 2437
HROMADNIKOVA ET AL., BIOMEDICINES, vol. 10, 2022, pages 718
HROMADNIKOVA ET AL., INT. J. MOL. SCI., vol. 23, 2022, pages 3951
Attorney, Agent or Firm:
MACHU, Matej (CZ)
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