Title:
METHOD FOR PREDICTION OF THERAPEUTIC EFFECT OF CHEMOTHERAPY EMPLOYING EXPRESSION LEVEL OF DIHYDROPYRIMIDINE DEHYDROGENASE GENE AS MEASURE
Document Type and Number:
WIPO Patent Application WO/2010/134588
Kind Code:
A1
Abstract:
Disclosed is a novel anti-tumor agent which has a higher life-span prolonging effect than those of standard therapies containing no dihydropyrimidine dehydrogenase inhibitor and containing 5-fluorouracil which have been practiced in Europe and United States.
The anti-tumor agent comprises a tegafur-gimeracil-oteracil potassium combination and cisplatin, for which advanced gastric cancer patients are selected by employing dihydropyrimidine dehydrogenase as a measure. The anti-tumor agent can exhibit a superior life-span prolonging effect than those of standard therapies containing no dihydropyrimidine dehydrogenase inhibitor and containing 5-fluorouracil which have been practiced in Europe and United States.
Inventors:
OKA TOSHINORI (JP)
Application Number:
PCT/JP2010/058597
Publication Date:
November 25, 2010
Filing Date:
May 21, 2010
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
OKA TOSHINORI (JP)
OKA TOSHINORI (JP)
International Classes:
C12N15/00; A61K31/282; A61K31/4412; A61K31/513; A61K31/53; A61K33/243; A61P35/00; A61P43/00; C12N15/09; C12Q1/68
Foreign References:
| JPS4910510B1 | 1974-03-11 |
Other References:
KOIZUMI, W. ET AL.: "S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial.", LANCET ONCOLOGY, vol. 9, 2008, pages 215 - 221, XP022497382
MASAKAZU FUKUSHIMA: "DIF ni Itaru Fukka Pyrimidine-kei Koganzai no Hensen", BIOTHERAPY, vol. 16, no. 4, 2002, pages 306 - 313, XP008158849
KURAMOCHI, H. ET AL.: "High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1.", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 63, no. 1, 2008, pages 85 - 89, XP019655066
TAKESHI YAMADA ET AL.: "Daichogan ni Okeru Orotate Phosphoribosyl Transferase(OPRT), Dihydropyrimidine Dehydrogenase(DPD), Thymidylate Synthase(TS) Kassei to Rinsho Byorigaku Kento", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, vol. 33, no. 6, 2006, pages 789 - 793, XP008158848
ISHIKAWA, Y. ET AL.: "Dihydropyrimidine Dehydrogenase Activity and Messenger RNA Level May Be Related to the Antitumor Effect of 5-Fluorouracil on Human Tumor Xenografts in Nude Mice.", CLINICAL CANCER RESEARCH, vol. 5, 1999, pages 883 - 889, XP002960712
YOSHIDA, K. ET AL.: "Challenge for a better combination with basic evidence.", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 13, no. 3, 2008, pages 212 - 219, XP019595332
CANCER, vol. 109, 2007, pages 33 - 40
J. CLIN. ONCOL, vol. 24, 2006, pages 663 - 667
INT. J. CANCER, vol. 119, 2006, pages 1927 - 1933
INT. J. CANCER, vol. 112, 2004, pages 967 - 973
J BIOL CHEM., vol. 269, no. 37, 1994, pages 23192 - 6
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1987, PUBLISH. JOHN WILEY AND SONS
See also references of EP 2436762A4
MASAKAZU FUKUSHIMA: "DIF ni Itaru Fukka Pyrimidine-kei Koganzai no Hensen", BIOTHERAPY, vol. 16, no. 4, 2002, pages 306 - 313, XP008158849
KURAMOCHI, H. ET AL.: "High intratumoral dihydropyrimidine dehydrogenase mRNA levels in pancreatic cancer associated with a high rate of response to S-1.", CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 63, no. 1, 2008, pages 85 - 89, XP019655066
TAKESHI YAMADA ET AL.: "Daichogan ni Okeru Orotate Phosphoribosyl Transferase(OPRT), Dihydropyrimidine Dehydrogenase(DPD), Thymidylate Synthase(TS) Kassei to Rinsho Byorigaku Kento", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, vol. 33, no. 6, 2006, pages 789 - 793, XP008158848
ISHIKAWA, Y. ET AL.: "Dihydropyrimidine Dehydrogenase Activity and Messenger RNA Level May Be Related to the Antitumor Effect of 5-Fluorouracil on Human Tumor Xenografts in Nude Mice.", CLINICAL CANCER RESEARCH, vol. 5, 1999, pages 883 - 889, XP002960712
YOSHIDA, K. ET AL.: "Challenge for a better combination with basic evidence.", INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, vol. 13, no. 3, 2008, pages 212 - 219, XP019595332
CANCER, vol. 109, 2007, pages 33 - 40
J. CLIN. ONCOL, vol. 24, 2006, pages 663 - 667
INT. J. CANCER, vol. 119, 2006, pages 1927 - 1933
INT. J. CANCER, vol. 112, 2004, pages 967 - 973
J BIOL CHEM., vol. 269, no. 37, 1994, pages 23192 - 6
AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1987, PUBLISH. JOHN WILEY AND SONS
See also references of EP 2436762A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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