Title:
METHOD FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2001042173
Kind Code:
A3
Abstract:
Process for the preparation of a diastereomerically enriched phenylglycine amide derivative in which an enantiomerically enriched phenylglycine amide is converted into the corresponding Schiff base with the aid of compound R2-C(O)-R3, and the Schiff base obtained is subsequently converted into the diastereomerically enriched phenylglycine amide derivative with the aid of a cyanide source, a reducing agent or an allyl organometallic compound. The phenylglycine amide derivatives obtained are interesting starting materials for the preparation of for example enantiomerically enriched alpha - and/or beta -amino acids and derivatives thereof, such as amides and esters, and amines.
Inventors:
BOESTEN WILHELMUS HUBERTUS JOS (NL)
MOODY HAROLD MONRO (NL)
KAPTEIN BERNARDUS (NL)
SEERDEN JOHANNES PAULUS GERARD (NL)
VAN DER SLUIS MARCELLES (NL)
LANGE DE BEN (NL)
BROXTERMAN QUIRINUS BERNARDUS (NL)
MOODY HAROLD MONRO (NL)
KAPTEIN BERNARDUS (NL)
SEERDEN JOHANNES PAULUS GERARD (NL)
VAN DER SLUIS MARCELLES (NL)
LANGE DE BEN (NL)
BROXTERMAN QUIRINUS BERNARDUS (NL)
Application Number:
PCT/NL2000/000892
Publication Date:
February 14, 2002
Filing Date:
December 04, 2000
Export Citation:
Assignee:
DSM NV (NL)
BOESTEN WILHELMUS H J (NL)
MOODY HAROLD MONRO (NL)
KAPTEIN BERNARDUS (NL)
SEERDEN JOHANNES PAULUS GERARD (NL)
SLUIS MARCELLES V D (NL)
LANGE DE BEN (NL)
BROXTERMAN QUIRINUS BERNARDUS (NL)
BOESTEN WILHELMUS H J (NL)
MOODY HAROLD MONRO (NL)
KAPTEIN BERNARDUS (NL)
SEERDEN JOHANNES PAULUS GERARD (NL)
SLUIS MARCELLES V D (NL)
LANGE DE BEN (NL)
BROXTERMAN QUIRINUS BERNARDUS (NL)
International Classes:
C07B53/00; C07B61/00; C07C209/50; C07C209/62; C07C211/03; C07C227/20; C07C227/32; C07C229/08; C07C231/06; C07C231/18; C07C237/06; C07C237/20; C07C253/00; C07C253/08; C07C253/30; C07C255/29; C07C255/42; C07D233/54; C07C233/06; C07C255/25; C07C255/43; (IPC1-7): C07C231/18; C07C253/08; C07C231/06; C07C227/32; C07C209/62; C07C255/25; C07C255/43; C07C237/20; C07C233/06; C07C237/06; C07C229/34; C07C229/08; C07C211/07
Domestic Patent References:
| WO1999047489A1 | 1999-09-23 | |||
| WO1998002410A1 | 1998-01-22 |
Foreign References:
| DE2200788A1 | 1973-07-12 |
Other References:
DATABASE WPI Section Ch Week 197645, Derwent World Patents Index; Class B05, AN 1976-84204X, XP002143436
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