Title:
METHOD FOR THE PREPARATION OF MEDETOMIDINE
Document Type and Number:
WIPO Patent Application WO/2012/172119
Kind Code:
A3
Abstract:
The invention discloses a method for the preparation of medetomidine starting from 1-bromo 2,3-dimethylbenzene and aceton.
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Inventors:
ZARAGOZA DOERWALD FLORENCIO (CH)
KULESZA ANNA (CH)
ELZNER STEPHAN (CH)
BUJOK ROBERT (PL)
WROBEL ZBIGNIEW (PL)
WOJCIECHOWSKI KRZYSZTOF (PL)
KULESZA ANNA (CH)
ELZNER STEPHAN (CH)
BUJOK ROBERT (PL)
WROBEL ZBIGNIEW (PL)
WOJCIECHOWSKI KRZYSZTOF (PL)
Application Number:
PCT/EP2012/070870
Publication Date:
April 04, 2013
Filing Date:
October 22, 2012
Export Citation:
Assignee:
LONZA AG (CH)
International Classes:
C07D233/58; C07C15/44; C07C33/20; C07C45/58; C07C47/228; C07D303/04
Domestic Patent References:
WO2009089132A1 | 2009-07-16 | |||
WO2012172120A2 | 2012-12-20 |
Foreign References:
GB2101114A | 1983-01-12 | |||
EP0058047A1 | 1982-08-18 | |||
DE2252080A1 | 1973-05-03 | |||
GB2453982A | 2009-04-29 |
Other References:
CORDI A A ET AL: "EFFICIENT SYNTHESIS OF (S)-4(5)-Ä1-(2,3-DIMETHYLPHENYL)ETHYLÜIMIDAZOLE TARTRATE, THE POTENT ALPHA2 ADRENOCEPTOR AGONIST DEXMEDETOMIDINE", SYNTHETIC COMMUNICATIONS: AN INTERNATIONAL JOURNAL FOR RAPID COMMUNICATION OF SYNTHETIC ORGANIC CHEMISTRY, TAYLOR & FRANCIS INC, PHILADELPHIA, PA; US, vol. 26, no. 8, 1996, pages 1585 - 1593, XP009014489, ISSN: 0039-7911, DOI: 10.1080/00397919608003527
ZHAO-RONG ZHANG ET AL: "ULTRASOUND-PROMOTED SYNTHESIS OF SUBSTITUTED PHENANTHRENE-1,4- QUINONES; THE STRUCTURE OF PLECTRANTHON D", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 14, 4 April 1994 (1994-04-04), pages 2153 - 2156, XP000434277, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)76783-9
CHARLES F HUEBNER ET AL: "THE ACONITE ALKAtOIDS XVI. ON STAPHISINE AND THE HYDROCARBON OBTAINED FROM ITS DEHYDROGENATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 169, 1947, pages 211 - 220, XP008157366, ISSN: 0021-9258
MUKHERJEE-MÜLLER ET AL: "176. Säurekatalysierte Umlagerungen von 1,5.Dimethyl-6-methyliden-tricyclo[3.2.1.0 2,7]oct-3-en-8endo-olen", HELVETICA CHIMICA ACTA,, vol. 60, no. 5, 1977, pages 1758 - 1780, XP002683671
ZHAO-RONG ZHANG ET AL: "ULTRASOUND-PROMOTED SYNTHESIS OF SUBSTITUTED PHENANTHRENE-1,4- QUINONES; THE STRUCTURE OF PLECTRANTHON D", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 35, no. 14, 4 April 1994 (1994-04-04), pages 2153 - 2156, XP000434277, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)76783-9
CHARLES F HUEBNER ET AL: "THE ACONITE ALKAtOIDS XVI. ON STAPHISINE AND THE HYDROCARBON OBTAINED FROM ITS DEHYDROGENATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 169, 1947, pages 211 - 220, XP008157366, ISSN: 0021-9258
MUKHERJEE-MÜLLER ET AL: "176. Säurekatalysierte Umlagerungen von 1,5.Dimethyl-6-methyliden-tricyclo[3.2.1.0 2,7]oct-3-en-8endo-olen", HELVETICA CHIMICA ACTA,, vol. 60, no. 5, 1977, pages 1758 - 1780, XP002683671
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