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Title:
METHOD FOR PREPARE CANGRELOR TETRASODIUM SALT
Document Type and Number:
WIPO Patent Application WO/2019/114674
Kind Code:
A1
Abstract:
The present application relates to a method for prepare a Cangrelor tetrasodium salt, comprising: using N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)sulfonyl]adenosine as a raw material to undergo two steps of reaction to obtain a reaction solution containing the Cangrelor tetrasodium salt; separating and purifying once by C18 silica gel column chromatography so as to obtain a Cangrelor tetrasodium salt pure product. The present application has the advantages of short synthesis route, mild reaction conditions, sufficient reaction, simple operation, high product yield, high purity, and environmental friendliness, and is suitable for large-scale preparation.

Inventors:
TANG FANGHUI (CN)
BAO JIYU (CN)
GAO JUNFENG (CN)
TAN ZHOUHONG (CN)
Application Number:
CN2018/120184
Publication Date:
June 20, 2019
Filing Date:
December 11, 2018
Export Citation:
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Assignee:
YABAO PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07H19/20
Domestic Patent References:
WO2018185715A12018-10-11
Foreign References:
CN1613864A2005-05-11
CN1119869A1996-04-03
CN201711318174A2017-12-12
CN1613864A2005-05-11
US9295687B12016-03-29
Other References:
INGALL, A.H. ET AL.: "Antagonists of the Platelet P2T Receptor: A Novel Approach to Antithrombotic Therapy", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 2, 28 January 1999 (1999-01-28), pages 213 - 220, XP002937224, DOI: doi:10.1021/jm981072s
J. MED. CHEM., vol. 12, 1999, pages 213 - 220
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 163706-58-9
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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