Title:
METHOD FOR PREPARING 16ALPHA-HYDROXYPREDNISOLONE
Document Type and Number:
WIPO Patent Application WO/2021/184502
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for preparing 16alpha-hydroxyprednisolone, belonging to the technical field of medicine preparation and processing. In the method, 21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione-21-acetate is used as a starting material, and subjected to oxidation, bromo-hydroxylation, debromination and alcoholysis, so as to prepare 16alpha-hydroxyprednisolone. The method for preparing 16alpha-hydroxylprednisolone of the present invention can effectively control the generation of impurities in the reaction process by improving the disadvantages of traditional processes, has a mild reaction process and a high overall conversion rate; and the method of the present invention has low requirements for a reaction device and low operation costs, is easy to operate, is suitable for industrial production, and has a good market prospect.
Inventors:
SHAO ZHENPING (CN)
WANG RONG (CN)
CHEN KEGANG (CN)
WANG BINGQIAN (CN)
WANG YOUFU (CN)
WANG RONG (CN)
CHEN KEGANG (CN)
WANG BINGQIAN (CN)
WANG YOUFU (CN)
Application Number:
PCT/CN2020/088692
Publication Date:
September 23, 2021
Filing Date:
May 06, 2020
Export Citation:
Assignee:
ZHEJIANG SHENZHOU PHARMACEUTICAL COMPANY LTD (CN)
International Classes:
C07J7/00
Domestic Patent References:
| WO2016120891A1 | 2016-08-04 | |||
| WO1989001482A1 | 1989-02-23 |
Foreign References:
| CN109384827A | 2019-02-26 | |||
| CN106905406A | 2017-06-30 | |||
| CN105566426A | 2016-05-11 | |||
| CN109575097A | 2019-04-05 | |||
| CN103724396A | 2014-04-16 | |||
| CN109851653A | 2019-06-07 | |||
| CN201310698900A | 2013-12-18 |
Attorney, Agent or Firm:
BEIJING HOFUWIN INTELLECTUAL PROPERTY LAW FIRM (CN)
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