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Title:
METHOD FOR PREPARING (2S,3R,4R)-3,5-DISUBSTITUTED-2-DEOXY-2-HYDROXY-2-METHYL-D-RIBOSE-Γ-LACTONE AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/095662
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing (2S,3R,4R)-3,5-disubstituted-2-deoxy-2-hydroxy-2-methyl-D-ribose-γ-lactone and an intermediate thereof. The intermediate has a structure represented by formula II. According to the present invention, a compound represented by formula II is used as an intermediate for preparing (2S,3R,4R)-3,5-disubstituted-2-deoxy-2-hydroxy-2-methyl-D-ribose-γ-lactone, so the stereoselectivity is good, the yield is high, the reaction condition is mild, and the raw material 2-C-methyl-D-ribonic acid-1,4-lactone for preparing the intermediate has wide sources, is simple to prepare and has low cost.

Inventors:
XIE YUANCHAO (CN)
TIAN GUANGHUI (CN)
JIANG XIANGRUI (CN)
Application Number:
PCT/CN2015/095356
Publication Date:
June 23, 2016
Filing Date:
November 24, 2015
Export Citation:
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Assignee:
SUZHOU VIGONVITA LIFE SCIENCES CO LTD (CN)
TOPHARMAN SHANGHAI CO LTD (CN)
SHANGHAI INST MATERIA MEDICA (CN)
International Classes:
C07D307/33; C07D307/68
Foreign References:
CN103420955A2013-12-04
Other References:
GAKHOKIDZE, R. A.; ET AL.: "Chemical Abstract 1991:82362 &, Synthesis of alpha-D-glucosaccharinic acid derivatives", IZVESTIYA AKADEMII NAUK GRUZINSKOI SSR, SERIYA KHIMICHESKAYA, vol. 16, no. 2, 31 December 1990 (1990-12-31)
GAKHOKIDZE, R. A.; ET AL.: "Chemical Abstract 1991:82362 &, Synthesis of alpha-D-glucosaccharinic acid derivatives", IZVESTIYA AKADEMII NAUK GRUZINSKOI SSR, SERIYA KHIMICHESKAYA, vol. 16, no. 2, 31 December 1990 (1990-12-31)
XIE, YUANCHAO ET AL.: "A neighboring group participation strategy: facile synthesis of 3,5-di-O-benzoyl-2-C-methyl-D-arabino-y-lactone", TETRAHEDRON LETTERS, vol. 56, no. 29, 28 May 2015 (2015-05-28), pages 4345 - 4348, XP029175351, DOI: doi:10.1016/j.tetlet.2015.05.085
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT & TRADEMARK AGENCY LTD. (CN)
苏州创元专利商标事务所有限公司 (CN)
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