Title:
METHOD FOR PREPARING 3-HYDROXY-4-NITROBENZALDEHYDE
Document Type and Number:
WIPO Patent Application WO/2023/040100
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of organic synthesis, and provides a method for preparing 3-hydroxy-4-nitrobenzaldehyde. In the present invention, dimethyl sulfoxide is used as a solvent for a reaction; and since dimethyl sulfoxide is a polar solvent and has good compatibility with both 3-hydroxybenzaldehyde and nitric acid, the degree of contact between 3-hydroxybenzaldehyde and nitric acid can be increased, and a high nitration conversion rate can be ensured even if the concentration of nitric acid is very low. In addition, a microchannel reaction apparatus has a large reaction specific surface area, can dissipate heat better, and can also further improve the nitration conversion rate. The data of the embodiments shows that the nitration conversion rate of the preparation method provided in the present invention is 36.4-97.3%, and the selectivity is 46.7-90.2%.
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| WO/1990/007480 | ACID CATALYZED PROCESS |
Inventors:
CHEN XIANLANG (CN)
WANG DEHUA (CN)
CHEN XIUXIU (CN)
LI RONGRONG (CN)
WU CHENGLIN (CN)
WANG DEHUA (CN)
CHEN XIUXIU (CN)
LI RONGRONG (CN)
WU CHENGLIN (CN)
Application Number:
PCT/CN2021/139393
Publication Date:
March 23, 2023
Filing Date:
December 18, 2021
Export Citation:
Assignee:
UNIV TAIZHOU (CN)
TAIZHOU BIOMEDICAL AND CHEMISTRY INDUSTRY RES INSTITUTE CO LTD (CN)
TAIZHOU BIOMEDICAL AND CHEMISTRY INDUSTRY RES INSTITUTE CO LTD (CN)
International Classes:
C07C201/08; B01J19/00; C07C205/44
Foreign References:
| CN107954876A | 2018-04-24 | |||
| CN111320545A | 2020-06-23 | |||
| CN102173992A | 2011-09-07 | |||
| CN1174829A | 1998-03-04 | |||
| CN1558894A | 2004-12-29 |
Other References:
CHEN BIFENG, WANG PENG, JIN QINGQING, TANG XINJING: "Chemoselective reduction and self-immolation based FRET probes for detecting hydrogen sulfide in solution and in cells", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 12, no. 30, 1 January 2014 (2014-01-01), pages 5629, XP093047790, ISSN: 1477-0520, DOI: 10.1039/C4OB00923A
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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