METHOD FOR PREPARING 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

Title:

METHOD FOR PREPARING 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

Document Type and Number:

WIPO Patent Application WO/2022/061920

Kind Code:

A1

Abstract:

A method for preparing 3',5'-dichloro-2,2,2-trifluoroacetophenone. The method comprises subjecting 3'-chloro-2,2,2-trifluoroacetophenone as a raw material to four steps, i.e. nitrification, reduction, chlorination and deamination, so as to prepare 3',5'-dichloro-2,2,2-trifluoroacetophenone. The method is low in terms of raw material cost, mild in terms of reaction conditions, simple in terms of reaction process, beneficial to reducing production cost, and the economic effect is improved.

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Inventors:

CAI GANGHUA (CN)
ZHANG LINGXIAO (CN)
TANG HONGYUAN (CN)
CHENG JINTAO (CN)

Application Number:

PCT/CN2020/118513

Publication Date:

March 31, 2022

Filing Date:

September 28, 2020

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Assignee:

TAIZHOU ABSOBIOTEC CO LTD (CN)
ZHEJIANG JIANGBEI NANHAI PHARMACEUTICAL CO LTD (CN)

International Classes:

C07C45/61; C07C49/80; C07C201/08; C07C205/45; C07C221/00; C07C225/22; C07C245/20

Domestic Patent References:

WO2012161313A1	2012-11-29
WO2018009751A1	2018-01-11

Foreign References:

JP2013006820A	2013-01-10
CN106518636A	2017-03-22
CN107353189A	2017-11-17

Attorney, Agent or Firm:

BEIJING WEIZHENG PATENT AGENCY CO., LTD. (CN)

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