Title:
METHOD FOR PREPARING 3,5-DIHALOTRIFLUOROACETOPHENONE AND DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/061914
Kind Code:
A1
Abstract:
The present application relates to the technical field of chemical pharmacy, and in particular, to a method for preparing 3,5-dihalotrifluoroacetophenone and a derivative thereof. 3-halogen-4-nitrotrifluoroacetophenone is used as a raw material, and the 3,5-dihalotrifluoroacetophenone derivative is finally obtained by means of a reduction reaction, a halogenation reaction and an amino substitution reaction. The raw material thereof is cheap and easily available, the process is simple, the conditions are mild, and the method has the prospect of large-scale production and has good economic effects.
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Inventors:
ZHANG LINGXIAO (CN)
CAI GANGHUA (CN)
TANG HONGYUAN (CN)
CHENG JINTAO (CN)
CAI GANGHUA (CN)
TANG HONGYUAN (CN)
CHENG JINTAO (CN)
Application Number:
PCT/CN2020/118495
Publication Date:
March 31, 2022
Filing Date:
September 28, 2020
Export Citation:
Assignee:
TAIZHOU ABSOBIOTEC CO LTD (CN)
ZHEJIANG JIANGBEI NANHAI PHARMACEUTICAL CO LTD (CN)
ZHEJIANG JIANGBEI NANHAI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C45/61; C07C45/63; C07C49/80; C07C49/825; C07C221/00; C07C225/22; C07C245/20
Domestic Patent References:
| WO2012161313A1 | 2012-11-29 | |||
| WO2015005408A1 | 2015-01-15 | |||
| WO2016058881A2 | 2016-04-21 |
Foreign References:
| JP2013006820A | 2013-01-10 | |||
| CN106518636A | 2017-03-22 | |||
| CN106795093A | 2017-05-31 | |||
| CN106795080A | 2017-05-31 | |||
| CN107353189A | 2017-11-17 | |||
| CN106795082A | 2017-05-31 | |||
| CN101827521A | 2010-09-08 | |||
| CN104812758A | 2015-07-29 |
Other References:
ZHAO, HAOYU: "Synthesis of 2,4,5-Trifluoroacetophenone", CHINESE JOURNAL OF PHARMACEUTICALS, vol. 42, no. 4, 31 December 2011 (2011-12-31), pages 254 - 255, XP055915604
Attorney, Agent or Firm:
BEIJING WEIZHENG PATENT AGENCY CO., LTD. (CN)
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