A METHOD FOR PREPARING 3D CARTILAGE ORGANOID BLOCK

WIPO Patent Application WO/2017/115982

A1

The present invention is to provide a 3D cartilage organoid block prepared by differentiating mesenchymal stem cells into 3D spheroid cartilage tissues, a basic unit for the 3D cartilage spheroid block. The inventors found that both the amount of GAG matrix and the expression of the collagen type2 increased. Therefore, the method of this invention provides clinically applicable cartilage tissues by effectively enhancing the function of the cartilage differentiation constructs according to 2D culture. The 3D cartilage organoid block can be usefully applied to the area, such as, articular cartilage regeneration and plastic aurgery, where cartilage tissues restoration is required.

SHIN YOUNG KEY (KR)
PARK SANG GYU (KR)
KIM YOUNG DEUG (KR)
AHN JONG CHAN (KR)
PARK BYOUNG JUN (KR)
LEE UI IL (KR)

PCT/KR2016/011037

July 06, 2017

October 01, 2016

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XCELL THERAPEUTICS INC (KR)

A61L27/36; A61K35/32; C12N5/077

KR101109668B1	2012-01-31
KR100839875B1	2008-06-19

BEACHLEY, V. ET AL.: "The fusion of tissue spheroids attached to pre-stretched electrospun polyurethane scaffolds", JOURNAL OF TISSUE ENGINEERING, vol. 5, 2014, pages 1 - 11, XP055396367
FLEMING, P. A. ET AL.: "Fusion of uniluminal vascular spheroids: a model for assembly of blood vessels", DEVELOPMENTAL DYNAMICS, vol. 239, 2010, pages 398 - 406, XP009164474
FENNEMA, E. ET AL.: "Spheroid culture as a tool for creating 3D complex tissues", TRENDS IN BIOTECHNOLOGY, vol. 31, 2013, pages 108 - 115, XP055086215

LEE, Jong Seung (KR)

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