Title:
METHOD FOR PREPARING ALBIFLORIN-6'-O-BENZENESULFONATE
Document Type and Number:
WIPO Patent Application WO/2023/236453
Kind Code:
A1
Abstract:
The present invention belongs to the field of compounds, and discloses a method for preparing albiflorin-6'-O-benzenesulfonate. The method comprises the following steps: taking a medicinal material that is rich in albiflorin as a starting material, subjecting same to extraction, adsorption, separation and purification to obtain albiflorin with a relatively high purity; and reacting an organic metal catalyst, an acid-binding agent and chemically active benzenesulfonyl chloride with albiflorin, carrying out column chromatography separation and refining on the product to obtain more than 98% of albiflorin-6'-O-benzenesulfonate, dissolving same in a mixed solvent, and carrying out programmed drying to finally obtain a finished product of albiflorin-6'-O-benzenesulfonate. The method has a high reaction yield, a simple operation, and mild conditions, and is very suitable for industrial production of albiflorin-6'-O-benzenesulfonate.
Inventors:
BAI BAI (CN)
XU WENDONG (CN)
LIU JUYAN (CN)
TANG SHUNZHI (CN)
YUAN CHENG (CN)
HAN YAMIN (CN)
PENG WANCAI (CN)
LIANG BEIMEI (CN)
WEI SHAOHENG (CN)
FU YUPIN (CN)
LI JIALI (CN)
XU WENDONG (CN)
LIU JUYAN (CN)
TANG SHUNZHI (CN)
YUAN CHENG (CN)
HAN YAMIN (CN)
PENG WANCAI (CN)
LIANG BEIMEI (CN)
WEI SHAOHENG (CN)
FU YUPIN (CN)
LI JIALI (CN)
Application Number:
PCT/CN2022/133498
Publication Date:
December 14, 2023
Filing Date:
November 22, 2022
Export Citation:
Assignee:
GUANGZHOU HANFANG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H17/04; C07H1/08
Foreign References:
| CN115677804A | 2023-02-03 | |||
| CN102643316A | 2012-08-22 | |||
| CN102603827A | 2012-07-25 | |||
| CN103044503A | 2013-04-17 | |||
| CN103951717A | 2014-07-30 |
Attorney, Agent or Firm:
SCIHEAD IP LAW FIRM (CN)
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