Title:
METHOD FOR PREPARING ANTI-ANGIOGENIC COMPOUND AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/188762
Kind Code:
A1
Abstract:
Disclosed is a method for preparing an anti-angiogenic compound represented by formula (I). The method comprises the step of reacting a compound of formula (II) with a compound of formula (III) in the presence of Cs2CO3 in a polar organic solvent to produce the compound of formula (I). According to the method of the present invention, by reacting the compound of formula (III) with the compound of formula (II) directly without protecting amino group in the compound of formula (III) under a certain condition, the yield is greatly improved, the synthetic method becomes simpler, the cost is also greatly reduced, and the commercial synthesis of the compound of formula (I) becomes possible. The preparation method for intermediate thereof is also disclosed.
Inventors:
HOU RUI (CN)
LUO HONGRONG (CN)
LUO HONGRONG (CN)
Application Number:
PCT/CN2015/081236
Publication Date:
December 17, 2015
Filing Date:
June 11, 2015
Export Citation:
Assignee:
NINGBO FANGCHANG MEDICAL CO LTD (CN)
International Classes:
C07D401/12; C07D215/50; C07D471/04; C07D487/04
Foreign References:
| CN1933839A | 2007-03-21 |
Other References:
HARMANGE, J.C. ET AL.: "Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 6, 7 March 2008 (2008-03-07), pages 1649 - 1667, XP002668409
Attorney, Agent or Firm:
BOSS & YOUNG PATENT AND TRADEMARK LAW OFFICE (CN)
北京邦信阳专利商标代理有限公司 (CN)
北京邦信阳专利商标代理有限公司 (CN)
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