Title:
METHOD FOR PREPARING ANTIGEN TO OBTAIN ANTIHYDROPHOBIC PEPTIDE ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2012/093706
Kind Code:
A1
Abstract:
The purpose of the present invention is to discover a method to obtain an antibody for hydrophobic peptides, which can be used for general purposes easily and with great reliability. This method for preparing an antigen is characterized in that hydrophobic peptides, which are not bonded to carrier proteins, are used as high molecular weight aggregates in an aqueous solution containing a nonionic surfactant.
Inventors:
OKAMOTO MASAJI (JP)
HANAMURA MASATO (JP)
FUKUSHIMA HITOSHI (JP)
YOSHIDA TETSUHIKO (JP)
HANAMURA MASATO (JP)
FUKUSHIMA HITOSHI (JP)
YOSHIDA TETSUHIKO (JP)
Application Number:
PCT/JP2012/050136
Publication Date:
July 12, 2012
Filing Date:
January 06, 2012
Export Citation:
Assignee:
TOAGOSEI CO LTD (JP)
SEIKO EPSON CORP (JP)
OKAMOTO MASAJI (JP)
HANAMURA MASATO (JP)
FUKUSHIMA HITOSHI (JP)
YOSHIDA TETSUHIKO (JP)
SEIKO EPSON CORP (JP)
OKAMOTO MASAJI (JP)
HANAMURA MASATO (JP)
FUKUSHIMA HITOSHI (JP)
YOSHIDA TETSUHIKO (JP)
International Classes:
C07K16/28; C07K17/02; G01N33/53
Domestic Patent References:
| WO2008125360A1 | 2008-10-23 |
Foreign References:
| JP2005511047A | 2005-04-28 | |||
| JPH07505389A | 1995-06-15 | |||
| JPH07132033A | 1995-05-23 | |||
| JP2011016763A | 2011-01-27 | |||
| US4981684A | 1991-01-01 | |||
| JPS59186921A | 1984-10-23 |
Other References:
BECK E. ET AL.: "Nucleotide sequence of the gene ompA coding the outer membrane protein II of Escherichia coli K-12", NUCLEIC ACIDS RESEARCH, vol. 8, no. 13, 1980, pages 3011 - 3027, XP055073363
MIRAGLIA SHERI ET AL.: "A Novel Five-Transmembrane Hematopoietic Stem Cell Antigen: Isolation, Characterization, and Molecular Cloning", BLOOD, vol. 90, no. 12, 1997, pages 5013 - 5021, XP002942327
"Antibodies; A LABORATORY MANUAL", 1988, COLD SPRING HARBOR LABORATORY
SHINOBU OHMI; KUNIO TSUJIMURA; MASAKI INAGAKI: "Experimental Protocol for Anti-Peptide Antibodies", 1994, SHUJUNSHA
M. S. ALMEN ET AL., BMC BIOLOGY, vol. 7, pages 50
P. F. SLIVKA ET AL., ACS CHEM. BIOL., vol. 3, no. 7, 2008, pages 402 - 411
0. BAKKE; T. W. NORDENG, IMMUNOL REV., vol. 172, 1999, pages 171 - 87
TAKESHI KOBAYASHI, J. BIOSCI. BIOENG., vol. 86, 2008, pages 384 - 386
TAM, J. P.: "Synthesis and properties of a high-density multiple antigenic peptide system", PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5409 - 5413, XP002611760, DOI: doi:10.1073/pnas.85.15.5409
SHINOBU OHMI; KUNIO TSUJIMURA; MASAKI INAGALD: "Experimental Protocol for Anti-Peptide Antibodies", 1994, SHUJUNSHA
ED HARLOW; DAVID LANE: "Antibodies; A LABORATORY MANUAL", 1988, COLD SPRING HARBOR LABORATORY
See also references of EP 2662389A4
MIRAGLIA SHERI ET AL.: "A Novel Five-Transmembrane Hematopoietic Stem Cell Antigen: Isolation, Characterization, and Molecular Cloning", BLOOD, vol. 90, no. 12, 1997, pages 5013 - 5021, XP002942327
"Antibodies; A LABORATORY MANUAL", 1988, COLD SPRING HARBOR LABORATORY
SHINOBU OHMI; KUNIO TSUJIMURA; MASAKI INAGAKI: "Experimental Protocol for Anti-Peptide Antibodies", 1994, SHUJUNSHA
M. S. ALMEN ET AL., BMC BIOLOGY, vol. 7, pages 50
P. F. SLIVKA ET AL., ACS CHEM. BIOL., vol. 3, no. 7, 2008, pages 402 - 411
0. BAKKE; T. W. NORDENG, IMMUNOL REV., vol. 172, 1999, pages 171 - 87
TAKESHI KOBAYASHI, J. BIOSCI. BIOENG., vol. 86, 2008, pages 384 - 386
TAM, J. P.: "Synthesis and properties of a high-density multiple antigenic peptide system", PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5409 - 5413, XP002611760, DOI: doi:10.1073/pnas.85.15.5409
SHINOBU OHMI; KUNIO TSUJIMURA; MASAKI INAGALD: "Experimental Protocol for Anti-Peptide Antibodies", 1994, SHUJUNSHA
ED HARLOW; DAVID LANE: "Antibodies; A LABORATORY MANUAL", 1988, COLD SPRING HARBOR LABORATORY
See also references of EP 2662389A4
Attorney, Agent or Firm:
MOEGI PATENT OFFICE (JP)
Patent business corporation It burns and is ぎ特許事務所. (JP)
Patent business corporation It burns and is ぎ特許事務所. (JP)
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