Title:
METHOD OF PREPARING ASENAPINE
Document Type and Number:
WIPO Patent Application WO/2021/027813
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing asenapine. Specifically, the present invention relates to a method for preparing a pharmaceutically acceptable asenapine free base and a crystal form thereof, as well as a method for preparing the intermediate compound used in the method.
Inventors:
ZHENG ZHIGUO (CN)
Application Number:
PCT/CN2020/108452
Publication Date:
February 18, 2021
Filing Date:
August 11, 2020
Export Citation:
Assignee:
ZHEJIANG AUSUN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D491/044; C07D207/08
Domestic Patent References:
| WO2013061247A1 | 2013-05-02 |
Foreign References:
| CN110606852A | 2019-12-24 | |||
| CN107759609A | 2018-03-06 | |||
| KR20150107357A | 2015-09-23 | |||
| CN101484456A | 2009-07-15 | |||
| IN201506331I4 | ||||
| CN104974168A | 2015-10-14 | |||
| US4145434A | 1979-03-20 | |||
| US20080009619A1 | 2008-01-10 | |||
| CN102229613A | 2011-11-02 | |||
| CN104974168A | 2015-10-14 | |||
| EP4015519A1 | 2022-06-22 |
Other References:
HONG-XING ZHENG , XIANG-HUAN SHAN, JIAN-PING QU , YAN-BIAO KANG: "Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem CâH and CâO Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans", ORGANIC LETTERS, vol. 20, no. 11, 18 May 2018 (2018-05-18), pages 3310 - 3313, XP055780618, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b01207
"Organic Chemistry", 28 February 2010, HENAN SCIENCE AND TECHNOLOGY PRESS, CN, ISBN: 978-7-5349-4249-5, article YIN ZHIGANG: "section 11.3, Diazonium Compound and Application Thereof", pages: 318 - 323, XP009525983
VADER, J.KASPERSEN, F.SPERLING, E.SCHLACHTER, ITERPSTRA, A.HILBERINK, PWAGENAARS, G, J. LABELLED COMPD. RADIOPHARM, vol. 34, 1994, pages 845 - 869
ORG. PROCESS RES. DEV., vol. 12, no. 2, 2008, pages 196 - 201
See also references of EP 4015519A4
"Organic Chemistry", 28 February 2010, HENAN SCIENCE AND TECHNOLOGY PRESS, CN, ISBN: 978-7-5349-4249-5, article YIN ZHIGANG: "section 11.3, Diazonium Compound and Application Thereof", pages: 318 - 323, XP009525983
VADER, J.KASPERSEN, F.SPERLING, E.SCHLACHTER, ITERPSTRA, A.HILBERINK, PWAGENAARS, G, J. LABELLED COMPD. RADIOPHARM, vol. 34, 1994, pages 845 - 869
ORG. PROCESS RES. DEV., vol. 12, no. 2, 2008, pages 196 - 201
See also references of EP 4015519A4
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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