Title:
METHOD FOR PREPARING ASYMMETRIC DISULFIDE
Document Type and Number:
WIPO Patent Application WO/2022/012036
Kind Code:
A1
Abstract:
The present invention relates to the technical field of fine chemical industry. Disclosed is a method for preparing asymmetric disulfide. The specific steps comprise: using 3-methylthio-N-phenylpropionamide and diphenyl disulfide as raw materials, using N-fluorobisbenzenesulfonamide as an additive, and preferably carrying out a reaction in an acetonitrile solvent under a heating condition so as to obtain a target product, i.e., symmetric disulfide N-phenyl-3-(phenyldithioalkyl)propionamide. The method is simple and convenient to operate and mild in reaction, uses 3-methylthio-N-phenylpropionamide and symmetric diphenyl disulfide as reaction raw materials, and efficiently synthesizes an asymmetric disulfide product in one step, thereby avoiding the use of a thiol raw material having unpleasant smell or a transition metal catalyst. The product has a potential application value.
Inventors:
YANG KE (CN)
SONG MENGJIE (CN)
LI YI (CN)
LI ZHENGYI (CN)
SUN XIAOQIANG (CN)
SONG MENGJIE (CN)
LI YI (CN)
LI ZHENGYI (CN)
SUN XIAOQIANG (CN)
Application Number:
PCT/CN2021/075467
Publication Date:
January 20, 2022
Filing Date:
February 05, 2021
Export Citation:
Assignee:
UNIV CHANGZHOU (CN)
International Classes:
C07C319/24; C07C323/62
Domestic Patent References:
| WO2004004659A2 | 2004-01-15 |
Foreign References:
| CN111777536A | 2020-10-16 | |||
| CN110615750A | 2019-12-27 | |||
| JP2004099508A | 2004-04-02 | |||
| JP2004161688A | 2004-06-10 | |||
| EP0563475A1 | 1993-10-06 |
Other References:
MAYER CHRISTOPH D.; ALLMENDINGER LARS; BRACHER FRANZ: "Synthesis of novel steroid analogues containing nitrile and disulfide moieties via palladium-catalyzed cross-coupling reactions", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, vol. 68, no. 6, 1 January 2012 (2012-01-01) - 13-12-2011, AMSTERDAM, NL , pages 1810 - 1818, XP028884904, ISSN: 0040-4020, DOI: 10.1016/j.tet.2011.11.076
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
Download PDF: