METHOD FOR PREPARING BIODEGRADABLE MICROSHERES USING STABILIZED SINGLE-PHASE MIXED SOLUTION

WIPO Patent Application WO/2019/208982

A1

The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.

LEE SANG HWI (KR)
KIM MIJUNG (KR)
JEONG DOOYONG (KR)
KIM MI JUNG (KR)
KIM WAN JOO (KR)
JOO SO KYOUNG (KR)

PCT/KR2019/004800

October 31, 2019

April 22, 2019

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CHEMTECH RES INCORPORATION (KR)

A61K9/16

KR101558083B1	2015-10-07
KR20160019020A	2016-02-18
KR20100101190A	2010-09-16
KR20090029339A	2009-03-23
KR101936040B1	2019-01-08
KR101558083B1	2015-10-07
KR101663560B1	2016-10-10

HIROTA, K. ET AL.: "Characterizing release mechanisms of leuprolide acetate-loaded PLGA microspheres for IVIVC development l", IN VITRO EVALUATION JOURNAL OF CONTROLLED RELEASE, vol. 244, 24 August 2016 (2016-08-24), pages 302 - 313, XP029850303, DOI: 10.1016/j.jconrel.2016.08.023
See also references of EP 3785704A4

CHO, Youngshin (KR)

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