Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
METHOD FOR PREPARING BIOMATERIAL HAVING SELECTIVELY FUNCTIONALIZED TYROSINE, BIOMATERIAL HAVING SELECTIVELY FUNCTIONALIZED TYROSINE, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/172605
Kind Code:
A1
Abstract:
Disclosed are a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing same as an active ingredient. The method for preparing a biomaterial to which a compound represented by chemical formula 2 is coupled, of the present invention, allows the compound represented by chemical formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

Inventors:
KIM, Byeong Moon (1 Gwanak-ro, Gwanak-gu, Seoul, 08826, KR)
LEE, Yan (1 Gwanak-ro, Gwanak-gu, Seoul, 08826, KR)
CHOI, Eun Joung (1 Gwanak-ro, Gwanak-gu, Seoul, 08826, KR)
JUNG, Dongwook (1 Gwanak-ro, Gwanak-gu, Seoul, 08826, KR)
Application Number:
KR2019/002512
Publication Date:
September 12, 2019
Filing Date:
March 05, 2019
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (1 Gwanak-ro, Gwanak-gu, Seoul, 08826, KR)
International Classes:
C07K14/505; A61K38/00; A61K47/60; C07K19/00; C12N9/76
Attorney, Agent or Firm:
LEE, Won Hee (8th Fl, Sung-ji Heights II 147, Teheran-ro,Gangnam-gu, Seoul, 06132, KR)
Download PDF: