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Title:
METHOD FOR PREPARING BIOMATERIAL HAVING SELECTIVELY FUNCTIONALIZED TYROSINE, BIOMATERIAL HAVING SELECTIVELY FUNCTIONALIZED TYROSINE, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/172605
Kind Code:
A1
Abstract:
Disclosed are a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing same as an active ingredient. The method for preparing a biomaterial to which a compound represented by chemical formula 2 is coupled, of the present invention, allows the compound represented by chemical formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

Inventors:
KIM BYEONG MOON (KR)
LEE YAN (KR)
CHOI EUN JOUNG (KR)
JUNG DONGWOOK (KR)
Application Number:
KR2019/002512
Publication Date:
September 12, 2019
Filing Date:
March 05, 2019
Export Citation:
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Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07K14/505; A61K38/00; A61K47/60; C07K19/00; C12N9/76
Foreign References:
KR20170104535A2017-09-15
Other References:
CHEN, W. ET AL.: "Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 23, 15 June 2016 (2016-06-15), pages 7353 - 7364, XP055637085
LI, S. ET AL.: "Direct introduction of R-SO2F moieties into proteins and protein-polymer conjugation using SuFEx chemistry", POLYMER, vol. 99, 2016, pages 7 - 12, XP029688939, doi:10.1016/j.polymer.2016.06.059
WANG, Y. -J. ET AL.: "PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: a comparison with glycosylated erythropoietin", JOURNAL OF CONTROLLED RELEASE, vol. 145, 2010, pages 306 - 313, XP027129716
FADEYI, O. O. ET AL.: "Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue", ACS CHEM. BIOL., vol. 12, no. 8, 18 July 2017 (2017-07-18), pages 2015 - 2020, XP055637091
CHOI, E. J. ET AL.: "Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction", CHEMISTRY-A EUROPEAN JOURNAL, vol. 24, 23 June 2018 (2018-06-23) - 18 July 2018 (2018-07-18), pages 10948 - 10952, XP055637099
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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