Title:
METHOD FOR PREPARING CHIRAL FERROCENE P, P LIGAND
Document Type and Number:
WIPO Patent Application WO/2017/177715
Kind Code:
A1
Abstract:
The present invention discloses a method for synthesizing a chiral ferrocene-like P, P ligand, and belongs to the technical field of organic synthesis. The method is implemented through the following steps: (1) using vinyl ferrocene as a starting material to react with a phosphine hydrogen compound in the presence of chiral catalyst to obtain ( R)-1-ferrocenyl ethyl diphosphine; and (2) after ( R)-1-ferrocenyl ethyl diphosphine reacts with diethylzinc, further reacting with a phosphine chloride compound to obtain a chiral ferrocene-like P, P ligand ( R)-(-)-1-[( S)-2-diphosphinyl ferrocene] ethyl diphosphine. Compared with the prior art, the present invention involves fewer steps, and is simple in operation and high in yield and thus is more suitable for industrial production. The prepared chiral ferrocene-like P, P compound can be used as a ligand of a metal catalyst in fields such as pharmaceutical synthesis.
Inventors:
CHEN HUI (CN)
YANG ZHENQIANG (CN)
ZHANG YINLONG (CN)
ZHAO SHUNWEI (CN)
ZHOU DUO (CN)
YANG RUINA (CN)
SUN MINQING (CN)
DUAN ZHENG (CN)
YANG ZHENQIANG (CN)
ZHANG YINLONG (CN)
ZHAO SHUNWEI (CN)
ZHOU DUO (CN)
YANG RUINA (CN)
SUN MINQING (CN)
DUAN ZHENG (CN)
Application Number:
PCT/CN2016/112288
Publication Date:
October 19, 2017
Filing Date:
December 27, 2016
Export Citation:
Assignee:
HENAN ACAD OF SCIENCES CHEMICAL RES INST CO LTD (CN)
International Classes:
C07F17/02; C07B53/00
Domestic Patent References:
| WO2016043254A1 | 2016-03-24 |
Foreign References:
| CN105859800A | 2016-08-17 |
Other References:
LI, YUFENG ET AL.: "Synthesis of (R)-l-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldi(3,5-dimethyphenyl)phosphine", FINE CHEMICALS, vol. 12, no. 28, 31 December 2011 (2011-12-31), pages 1236 - 1239
Attorney, Agent or Firm:
ZHENGZHOU LIANKE PATENT AGENCY (COMMON PARTNERSHIP) (CN)
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