Title:
METHOD FOR PREPARING CHIRAL β-HYDROXYLCARBOXYLATE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/031246
Kind Code:
A1
Abstract:
The present application discloses a method for preparing a chiral β-hydroxylcarboxylate compound, involving firstly dissolving a dichlorophenyl ruthenium dimer, a ligand and an alkaline additive in a solvent under the protection of an inert gas, and stirring same at room temperature to produce a catalyst in situ; and then dissolving the substrate β-carbonylcarboxylate in a solvent, adding same to the prepared catalyst, introducing hydrogen and subjecting the substrate β-carbonylcarboxylate to an asymmetric catalytic hydrogenation reaction, wherein the reaction conditions are as follows: the pressure is 10-100 atmospheres, the reaction temperature is 0-200ºC, and the reaction time is 12-48 hours. The invention has a high reaction activity and selectivity, mild hydrogenation reaction conditions, is suitable for a variety of β-carbonylcarboxylates, and has a wide substrate application range and a small amount of environmental pollution created during the reaction process.
Inventors:
HU XINHU (CN)
HU YANWANG (CN)
HU YANWANG (CN)
Application Number:
PCT/CN2019/104631
Publication Date:
February 25, 2021
Filing Date:
September 06, 2019
Export Citation:
Assignee:
SHANGHAI SHINE HIGH INT TRADE CO LTD (CN)
HU XINHU (CN)
HU YANWANG (CN)
HU XINHU (CN)
HU YANWANG (CN)
International Classes:
C07C67/31; B01J31/24; C07C69/675; C07C69/732
Foreign References:
| CN110330429A | 2019-10-15 | |||
| CN110003005A | 2019-07-12 |
Other References:
ZHAOGUO ZHANG ET AL.: "Synthesis of chiral bisphosphines with tunable bite angles and their applications in asymmetric hydrogenation of β-ketoesters", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 65, no. 19, 19 August 2000 (2000-08-19), XP002214812, ISSN: 1520-6904, DOI: 20200518140107
Attorney, Agent or Firm:
SHANGHAI HONSIN INTELLECTUAL PROPERTY OFFICE (CN)
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